Document Detail


The effect of diethylhydroxylamine on the incidence of tumors induced by benzo(a)pyrene in the mouse.
MedLine Citation:
PMID:  6489187     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Groups of 20 male and 20 female CD-1(ICR)Br mice were treated either with 0, 3, 30, or 300 mg diethylhydroxylamine (DEHA)/kg-day (administered via the drinking water) from 57-112 days of age. For the four week period between 70 to 98 days of age, all animals received (via gavage) eight 1 mg doses of benzo(a)pyrene at 4 day intervals. One hundred thirty-seven animals survived the dosing period. Of these, 132 survived to 211 days of age at which time they were euthanized and necropsied. Gross lesions were observed only in the lungs and squamous portion of the stomach. Treatment with DEHA produced no significant effect on the lung tumor incidence of either sex. However, a significant increase in stomach tumors was observed in the females.
Authors:
J Heicklen; T Wilson; G D Miller; E J Massaro
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Drug and chemical toxicology     Volume:  7     ISSN:  0148-0545     ISO Abbreviation:  Drug Chem Toxicol     Publication Date:  1984  
Date Detail:
Created Date:  1984-12-03     Completed Date:  1984-12-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7801723     Medline TA:  Drug Chem Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  315-27     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aging
Animals
Benzo(a)pyrene / antagonists & inhibitors*
Body Weight / drug effects
Female
Hydroxylamines / pharmacology*
Lung Neoplasms / chemically induced
Male
Mice
Mice, Inbred ICR
Neoplasms, Experimental / chemically induced*
Sex Factors
Stomach Neoplasms / chemically induced
Chemical
Reg. No./Substance:
0/Hydroxylamines; 3710-84-7/N,N-diethylhydroxylamine; 50-32-8/Benzo(a)pyrene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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