| The effect of dietary supplementation with limonene or myo-inositol on the induction of neoplasia and matrix metalloproteinase and plasminogen activator activities in accessory sex organs of male Lobund-Wistar rats. | |
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MedLine Citation:
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PMID: 18675799 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prostate cancer, the most prevalent non-cutaneous cancer in men, is associated with increased age. This suggests that dietary chemopreventive measures could be effective in delaying the onset or decreasing the severity of the disease. We utilized the Lobund-Wistar rat nitrosomethylurea induced, testosterone promoted (NMU-T) model of male sex accessory gland cancer to test the potential chemopreventive effects of myo-inositol and limonene on tumor incidence and associated protease activities. Tumors were found to arise in the seminal vesicles and dorsal and anterior prostate lobes. There were also some tumors that appeared to arise in both the seminal vesicles and anterior prostate, and in some cases the tissue of origin was not clear. The distribution of tumors as to site of origin in limonene or myo-inositol treated animals did not vary from that of the starch fed control animals, and the number of animals presenting with metastases did not vary significantly between treatment groups. There was a statistically significant delay in onset of tumors in myo-inositol, but not limonene fed rats, at 10 months post-induction of carcinogenesis; however, at 12 and 15 months this was not significant. The ventral prostate and seminal vesicles expressed pro-MMP-2 and plasminogen activator (PA) activities. Based on sensitivity to amiloride, the PA activities were predominately urokinase (uPA) in the ventral prostate and a mixture of tissue-type activator (tPA) and uPA in the seminal vesicles of non-treated rats. Sex accessory gland tumors, and metastases, expressed increased levels PA and pro- and active forms of MMP-2 and -9. The PA activities of the tumors were a mixture of uPA and tPA. There was no difference in the levels of these protease activities based on the tissue of tumor origin, nor in tumor vs metastasis. These studies indicate that MMP and PA activities play a role in sex accessory gland tumor biology and that dietary supplementation with myo-inositol can delay but not ultimately prevent the development of such tumors. |
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Authors:
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Michael J Wilson; Bruce R Lindgren; Akhouri A Sinha |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2008-07-17 |
Journal Detail:
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Title: Experimental and molecular pathology Volume: 85 ISSN: 1096-0945 ISO Abbreviation: Exp. Mol. Pathol. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-17 Completed Date: 2008-11-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370711 Medline TA: Exp Mol Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 83-9 Citation Subset: IM |
Affiliation:
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VA Medical Center, University of Minnesota, Minneapolis, MN 55417, USA. wilso042@umn.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alkylating Agents
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toxicity Animals Anticarcinogenic Agents / therapeutic use Cyclohexenes / therapeutic use* Dietary Supplements* Disease Models, Animal Genitalia, Male / enzymology, metabolism, pathology* Incidence Inositol / therapeutic use* Male Matrix Metalloproteinases / analysis, biosynthesis* Methylnitrosourea / toxicity Neoplasms / chemically induced, prevention & control* Plasminogen Activators / analysis, metabolism* Random Allocation Rats Rats, Wistar Terpenes / therapeutic use* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Alkylating Agents; 0/Anticarcinogenic Agents; 0/Cyclohexenes; 0/Terpenes; 138-86-3/limonene; 684-93-5/Methylnitrosourea; 6917-35-7/Inositol; EC 3.4.21.-/Plasminogen Activators; EC 3.4.24.-/Matrix Metalloproteinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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