Document Detail

The effect of dietary sodium intake on the blood pressure and cardiac output responses to angiotensin II in unanaesthetized rats.
MedLine Citation:
PMID:  884929     Owner:  NLM     Status:  MEDLINE    
1. Dose-response curves for the pressor activity of angiotensin II have been determined in unanaesthetized rats receiving diets containing 2-5% (w/w) or 0-007% (w/w) sodium and administered in various sequences. 2. Dose-response curves were shifted to the left in rats on a high-, compared with a low-, sodium intake. This response was maintained for 7 days on changing from high to low sodium. 3. There was no difference in the relation between the fall of cardiac output and the rise of blood pressure in any of the experimental groups. 4. Dose-response curves for peripheral resistance showed the same directional change as seen for the pressor response in rats on high- and low-sodium diets. Since depression of cardiac output was proportional to the pressure rise, the absolute change in peripheral resistance was greater than the blood pressure response. The proportional changes were similar. 5. It is concluded that alterations in the pressor response to angiotensin caused by changes in sodium loading are attributable to changes in peripheral resistance and not to changes in the cardiac output response to the acute rise in blood pressure.
B L Slack; J M Ledingham
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical science and molecular medicine     Volume:  52     ISSN:  0301-0538     ISO Abbreviation:  Clin Sci Mol Med     Publication Date:  1977 Jun 
Date Detail:
Created Date:  1977-09-22     Completed Date:  1977-09-22     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0367540     Medline TA:  Clin Sci Mol Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  571-6     Citation Subset:  IM    
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MeSH Terms
Angiotensin II / administration & dosage,  pharmacology*
Blood Pressure / drug effects*
Cardiac Output / drug effects*
Dose-Response Relationship, Drug
Sodium / pharmacology*
Reg. No./Substance:
11128-99-7/Angiotensin II; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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