| The effect of dietary restriction on gastrin secretion in the obese Zucker rat. | |
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MedLine Citation:
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PMID: 2228404 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has been hypothesized that G-cell hyperplasia secondary to increased food consumption in the obese Zucker rat was responsible for the hypergastrinemia observed in vivo and from the isolated perfused stomach preparation. This possibility was investigated in pair-feeding experiments wherein the food intake of obese animals was restricted to match that of lean littermates from 5 to 8 weeks of age. Dietary restriction reduced the antral G-cell population of the obese rat to a similar level as that seen in lean animals, supporting the view that hyperphagia is the trigger for G-cell hyperplasia. However, basal gastrin levels measured in vivo and in vitro from the stomach preparation of the pair-fed obese animals were not significantly lower than those of obese animals fed ad libitum. Thus, abnormal feeding behavior in the obese phenotype cannot be directly related to gastrin hypersecretion and G-cell hyperplasia is not the primary cause of hypergastrinemia. |
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Authors:
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R V Campos; R A Pederson; A M Buchan; J C Brown |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of obesity Volume: 14 ISSN: 0307-0565 ISO Abbreviation: Int J Obes Publication Date: 1990 Aug |
Date Detail:
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Created Date: 1990-12-19 Completed Date: 1990-12-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7703240 Medline TA: Int J Obes Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 723-31 Citation Subset: IM |
Affiliation:
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Department of Physiology, University of British Columbia, Vancouver, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Weight / physiology Diet* Eating / physiology* Gastrins / blood, secretion* Models, Biological Obesity / etiology, physiopathology* Pyloric Antrum / secretion* Rats Rats, Zucker |
| Chemical | |
Reg. No./Substance:
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0/Gastrins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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