| The effect of dietary raw and autoclaved soya-bean protein fractions on growth, pancreatic enlargement and pancreatic enzymes in rats. | |
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MedLine Citation:
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PMID: 7199936 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Raw soya-bean meal (RS) was fractionated into soya-bean lyophilized extract (SLE), soya-bean lyophilized residue (SLR), acid-precipitated proteins (APP) and whey proteins. 2. Trypsin (EC 3. 4. 21. 4)and chymotrypsin (EC 3. 4. 21.1) inhibitors (TI) were soluble at pH 8 and remained soluble after the extract was acidified to pH 4.4 Except for whey, heating abolished, almost totally, their inhibiting activity. 3. Feeding SLE diet (high TI content) and APP diet (low TI content) resulted in growth depression below the RS level. Feeding the SLR diet resulted in an optimal growth. Feeding diets containing heated fractions improved the growth rate though not to the level observed with heated RS (HS) diet. 4. RS, SLE, APP and whey diets produced similar pancreatic enlargement which could be totally (RS, whey) or partially (SLE, APP) abolished by heating. 5. Feeding the RS diet reduced pancreatic amylase content. The factor responsible for this effect cofractionated with SLE and whey proteins. 6. Two groups of factors in the various diets were probably responsible for the elevation in pancreatic proteases. The first group were the heat-labile factors present in RS, SLE and whey whereas the second group resisted the heat treatment and were found in APP and SLR. 7. The results suggest that for optimal growth rate of rats, heat treatment should be given to the unfractionated soya-bean proteins rather than to the isolated fractions. The results further indicated that TI are not the only factors that can lead to pancreatic enlargement and changes in pancreatic enzymes composition. |
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Authors:
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M Naim; A Gertler; Y Birk |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The British journal of nutrition Volume: 47 ISSN: 0007-1145 ISO Abbreviation: Br. J. Nutr. Publication Date: 1982 Mar |
Date Detail:
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Created Date: 1982-06-21 Completed Date: 1982-06-21 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 281-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chymotrypsin / antagonists & inhibitors Dietary Proteins / pharmacology* Growth / drug effects Hot Temperature Male Organ Size / drug effects Pancreas / anatomy & histology, enzymology* Rats Soybeans* Trypsin Inhibitors / metabolism Vegetable Proteins / analysis, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Dietary Proteins; 0/Trypsin Inhibitors; 0/Vegetable Proteins; EC 3.4.21.1/Chymotrypsin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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