Document Detail


The effect of dietary protein on the efficacy of L-dopa: a double-blind study.
MedLine Citation:
PMID:  2494567     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We randomly placed 10 parkinsonian patients on high- and low-protein diets that tasted and looked alike, each for 1 week. All patients were taking L-dopa and carbidopa with or without other antiparkinson medications; medications remained unchanged. A "blind" physician recorded the modified Columbia scores, objective measurements of rigidity, movement velocity, and pegboard tests three times a day for 5 days during each week. The patients recorded fluctuations hour to hour. We measured serial blood L-dopa levels on day 4 of each week. Performance was significantly better while the patients were on low-protein diets. These results did not correlate with blood L-dopa levels, which had higher peaks in three patients while they were on high-protein diets despite inferior performance and increased number of "off" hours. Thus, high dietary protein probably affects the efficacy of L-dopa at a central level.
Authors:
J K Tsui; S Ross; K Poulin; J Douglas; D Postnikoff; S Calne; W Woodward; D B Calne
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Neurology     Volume:  39     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-05-10     Completed Date:  1989-05-10     Revised Date:  2009-10-06    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  549-52     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, University Hospital, University of British Columbia, Vancouver, Canada.
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MeSH Terms
Descriptor/Qualifier:
Antiparkinson Agents / therapeutic use*
Bromocriptine / therapeutic use
Carbidopa / therapeutic use*
Clinical Trials as Topic
Dietary Proteins*
Double-Blind Method
Drug Combinations / therapeutic use
Drug Therapy, Combination
Female
Humans
Levodopa / therapeutic use*
Male
Middle Aged
Parkinson Disease / diet therapy,  drug therapy,  physiopathology*
Random Allocation
Selegiline / therapeutic use
Chemical
Reg. No./Substance:
0/Antiparkinson Agents; 0/Dietary Proteins; 0/Drug Combinations; 0/Levodopa; 0/carbidopa, levodopa drug combination; 14611-51-9/Selegiline; 25614-03-3/Bromocriptine; 38821-49-7/Carbidopa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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