| The effect of dietary protein deprivation on protein synthesis in the isolated liver parenchymal cell. | |
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MedLine Citation:
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PMID: 911744 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Parenchymal cells were isolated from the liver of rats that had been deprived of dietary protein for 3 weeks. 2. The cells were two-thirds the diameter of those derived from livers of normal animals and consumed oxygen at a rate of 16-2 +/- 2-7 mu1/h per 10(6) viable cells, half the normal value. 3. Albumin and transferrin were synthesized at rates of 0-94 +/- 0-12 and 0-60 +/- 0-07 microgram/h per 10(6) viable cells respectively and urea at a rate of 0-77 +/- 0-12 microgram/h per 10(6) cells. This represents a 25-50% decrease in the rates of synthesis measured in cells isolated from normal livers. 4. The results are discussed in relation to the long-term effects of malnutrition on liver cell function. |
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Authors:
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A G Grant; R Hoffenberg |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The British journal of nutrition Volume: 38 ISSN: 0007-1145 ISO Abbreviation: Br. J. Nutr. Publication Date: 1977 Sep |
Date Detail:
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Created Date: 1977-12-29 Completed Date: 1977-12-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 255-60 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Albumins
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biosynthesis Animals Cells, Cultured Dietary Proteins / administration & dosage Liver / metabolism* Male Oxygen Consumption Protein Biosynthesis* Protein Deficiency / metabolism* Rats Transferrin / biosynthesis Urea / biosynthesis |
| Chemical | |
Reg. No./Substance:
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0/Albumins; 0/Dietary Proteins; 11096-37-0/Transferrin; 57-13-6/Urea |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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