Document Detail

The effect of dietary protein deprivation on protein synthesis in the isolated liver parenchymal cell.
MedLine Citation:
PMID:  911744     Owner:  NLM     Status:  MEDLINE    
1. Parenchymal cells were isolated from the liver of rats that had been deprived of dietary protein for 3 weeks. 2. The cells were two-thirds the diameter of those derived from livers of normal animals and consumed oxygen at a rate of 16-2 +/- 2-7 mu1/h per 10(6) viable cells, half the normal value. 3. Albumin and transferrin were synthesized at rates of 0-94 +/- 0-12 and 0-60 +/- 0-07 microgram/h per 10(6) viable cells respectively and urea at a rate of 0-77 +/- 0-12 microgram/h per 10(6) cells. This represents a 25-50% decrease in the rates of synthesis measured in cells isolated from normal livers. 4. The results are discussed in relation to the long-term effects of malnutrition on liver cell function.
A G Grant; R Hoffenberg
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The British journal of nutrition     Volume:  38     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  1977 Sep 
Date Detail:
Created Date:  1977-12-29     Completed Date:  1977-12-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  255-60     Citation Subset:  IM    
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MeSH Terms
Albumins / biosynthesis
Cells, Cultured
Dietary Proteins / administration & dosage
Liver / metabolism*
Oxygen Consumption
Protein Biosynthesis*
Protein Deficiency / metabolism*
Transferrin / biosynthesis
Urea / biosynthesis
Reg. No./Substance:
0/Albumins; 0/Dietary Proteins; 11096-37-0/Transferrin; 57-13-6/Urea

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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