Document Detail

The effect of dietary oils on cecal microflora in experimental colitis in mice.
MedLine Citation:
PMID:  19112187     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: In spite of growing evidence indicating the benefits of probiotics, the effects of different dietary oils on intestinal microflora and probiotics have not been elucidated. This study aimed to examine the effects of different dietary oils on intestinal microflora in an experimental model of colitis. METHODS: Eight-week mice were fed isocaloric diets varying only in fat composition for 4 weeks. The oils used were fish oil, canola oil, safflower oil, and chow diet containing beef tallow. Colitis was induced by intracolonic administration of acetic acid on day 21. The inflammation and fecal microflora and serum lipid profiles were evaluated 1 week after induction. RESULTS: Inflammation was highest in the chow diet group followed by safflower, canola, and fish oil fed groups, respectively. The number of fecal bacteroideceae was greater, whereas the number of fecal bifidobacteria was lower in mice fed beef tallow than the other ones. In addition, fish oil reduced the plasma level of triacylglycerole significantly. CONCLUSION: Polyunsaturated fatty acids (PUFAs) can affect intestinal microflora increasing the number of probiotics. PUFAs might be recommended in addition to probiotics for the prevention and/or maintenance treatment of colitis.
Azita Hekmatdoost; Mohammad M Feizabadi; Abolghasem Djazayery; Abbas Mirshafiey; Mohammad R Eshraghian; Samira M Yeganeh; Reza Sedaghat; Kevan Jacobson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology     Volume:  27     ISSN:  0975-0711     ISO Abbreviation:  Indian J Gastroenterol     Publication Date:    2008 Sep-Oct
Date Detail:
Created Date:  2008-12-29     Completed Date:  2009-07-23     Revised Date:  2010-06-16    
Medline Journal Info:
Nlm Unique ID:  8409436     Medline TA:  Indian J Gastroenterol     Country:  India    
Other Details:
Languages:  eng     Pagination:  186-9     Citation Subset:  IM    
Department of Human Nutrition, School of Health, Tehran University of Medical Sciences, Tehran, Iran.
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MeSH Terms
Acetic Acids / pharmacology
Cecum / microbiology*
Colitis / chemically induced,  diet therapy*
Dietary Fats, Unsaturated / pharmacology,  therapeutic use*
Disease Models, Animal
Fatty Acids, Unsaturated / pharmacology,  therapeutic use
Lipids / blood*
Mice, Inbred BALB C
Reg. No./Substance:
0/Acetic Acids; 0/Dietary Fats, Unsaturated; 0/Fatty Acids, Unsaturated; 0/Lipids

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