| The effect of dietary manipulation on hepatic lipid accumulation in rats undergoing small intestinal bypass. | |
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MedLine Citation:
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PMID: 2862126 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Small intestinal bypass performed for morbid obesity produces hepatic fat infiltration which persists in some patients for more than 5 years. In an attempt to define causative and preventative factors of hepatic steatosis following small intestinal bypass, a rat model was developed. In this study, nutritionally obese rats underwent sham operations or bypass of 90 per cent of their small intestine and postoperatively were fed various diets to determine the effects of dietary manipulations on hepatic lipid content. After 30 days the rats were killed and their hepatic lipid content and lipogenic enzyme activity determined. In rats that underwent intestinal bypass neither a high fat, a high carbohydrate nor a high protein diet increased hepatic lipid content over that present in sham operated animals. A low (4.5 per cent) protein diet increased total hepatic lipid and hepatic triglyceride content. The increased triglyceride levels were not associated with significant changes in lipogenic enzyme activity and were associated with decreased serum triglycerides suggesting impaired triglyceride transport from the liver secondary to decreased lipoprotein formation as a possible etiologic mechanism. A significant inverse relationship was found between hepatic triglyceride content and hepatic protein content. These results support previous reports from human studies of hypoproteinemia associated with hepatic steatosis following small intestinal bypass. |
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Authors:
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D L Kaminski; E Mueller; M Jellinek |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: International journal of obesity Volume: 9 ISSN: 0307-0565 ISO Abbreviation: Int J Obes Publication Date: 1985 |
Date Detail:
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Created Date: 1985-09-11 Completed Date: 1985-09-11 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7703240 Medline TA: Int J Obes Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 59-68 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetyl-CoA Carboxylase
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metabolism Animals Cholesterol / metabolism Dietary Carbohydrates / therapeutic use* Dietary Fats / therapeutic use* Dietary Proteins / therapeutic use* Disease Models, Animal Fatty Acid Synthetase Complex / metabolism Fatty Liver / prevention & control Intestine, Small / surgery* Lipid Metabolism* Liver / enzymology, metabolism* Male Obesity / therapy Phospholipids / metabolism Rats Rats, Inbred Strains Serum Albumin / metabolism Triglycerides / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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AM 19343/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dietary Carbohydrates; 0/Dietary Fats; 0/Dietary Proteins; 0/Phospholipids; 0/Serum Albumin; 0/Triglycerides; 57-88-5/Cholesterol; EC 6.-/Fatty Acid Synthetase Complex; EC 6.4.1.2/Acetyl-CoA Carboxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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