Document Detail

The effect of dietary fatty acid manipulation on phagocytic activity and cytokine production by peritoneal cells from Balb/c mice.
MedLine Citation:
PMID:  9591234     Owner:  NLM     Status:  MEDLINE    
Previous studies have demonstrated that dietary lipid manipulation may modify immune response by affecting lymphocyte proliferation, phagocytosis, cytokine production, etc. In this paper, we investigated the effect of olive oil (OO) on the phagocytic activity and cytokine production by murine peritoneal cells. These results were compared with those obtained from mice fed diets containing sunflower oil (SO) or hydrogenated coconut oil (HCO). Balb/c mice were divided into three groups and fed diets containing 15% by weight of either OO, SO or HCO for 5, 15, 30, 60 or 90 d. Phagocytic activity and interleukin-1 (IL-1) production were increased in OO-fed mice as compared to the other groups. On the contrary, no significant differences were observed in the levels of tumor necrosis factor (TNF) production, although the levels of this cytokine were slightly increased in mice fed the OO diet. These observations suggest that OO is able to modify the immune response and therefore, it may be used as an immunomodulatory agent.
M A de Pablo; E Ortega; A M Gallego; C Alvarez; P L Pancorbo; G Alvarez de Cienfuegos
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of nutritional science and vitaminology     Volume:  44     ISSN:  0301-4800     ISO Abbreviation:  J. Nutr. Sci. Vitaminol.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-07-16     Completed Date:  1998-07-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0402640     Medline TA:  J Nutr Sci Vitaminol (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  57-67     Citation Subset:  IM    
Department of Health Sciences, University of Jaén, Spain.
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MeSH Terms
Body Weight
Cell Count
Cytokines / biosynthesis*
Dietary Fats, Unsaturated / administration & dosage*
Fatty Acids / administration & dosage*
Interleukin-1 / biosynthesis
Mice, Inbred BALB C
Peritoneum / cytology*,  immunology*
Plant Oils
Tumor Necrosis Factor-alpha / biosynthesis
Reg. No./Substance:
0/Cytokines; 0/Dietary Fats, Unsaturated; 0/Fatty Acids; 0/Interleukin-1; 0/Plant Oils; 0/Tumor Necrosis Factor-alpha; 8001-25-0/olive oil

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