Document Detail

The effect of diet on retention by the rat of iron from a radiolabeled casein test meal.
MedLine Citation:
PMID:  4038737     Owner:  NLM     Status:  MEDLINE    
Previous work has shown that weanling rats fed a soy protein isolate (SPI)-based diet retained less iron from a casein test meal than did rats fed a casein-based diet. In the present work this diet effect was further investigated. In experiment 1 rats were fed either SPI-or casein-based diet (about 25 ppm Fe) for 13 d, fasted overnight, given a 59Fe-labeled casein-based test meal, and refed either the same or the other diet for 7 d. 59Fe retention was determined by the percent of ingested label retained after 7 d. SPI reduced 59Fe retention when fed prior to the test meal (52.5 vs. 61.5%, P less than 0.001) and also when fed following the test meal (50.8 vs. 63.2%, P less than 0.001). In experiment 2a, exposure of SPI to steam at 108 degrees C for 30 min did not lessen the observed diet effect. In experiment 2b rats were fed either an SPI-or casein-based diet, and casein test meals were fed as above on days 14, 35 and 56. The SPI-based diet reduced 59Fe retention from the casein test meal fed on d 14 (58.2 vs. 68.0%, P less than 0.005), for the meal on d 35 there was no difference, and for the final test meal rats fed SPI retained more 59Fe (53.0 vs. 40.2%, P less than 0.01). In experiment 3 lactalbumin was shown to decrease 59Fe retention to the same extent as SPI (54.9 and 53.4%) as compared to casein (73.3%), whereas neither rapeseed protein concentrate (68.8%) nor oxalic acid (72.2%) had any significant adverse effect.(ABSTRACT TRUNCATED AT 250 WORDS)
D B Thompson; J W Erdman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of nutrition     Volume:  115     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  1985 Mar 
Date Detail:
Created Date:  1985-04-18     Completed Date:  1985-04-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  319-26     Citation Subset:  IM    
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MeSH Terms
Body Weight
Caseins / metabolism*
Dietary Proteins / pharmacology*
Hemoglobins / metabolism
Iron / metabolism*
Plant Proteins / pharmacology
Rats, Inbred Strains
Reg. No./Substance:
0/Caseins; 0/Dietary Proteins; 0/Hemoglobins; 0/Plant Proteins; 7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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