Document Detail

The effect of diet on the Vervet monkey endocrine pancreas.
MedLine Citation:
PMID:  9438224     Owner:  NLM     Status:  MEDLINE    
Vervet monkeys (Cercopithecus aethiops) used for pancreatic endocrine cell distribution studies were found to have been maintained on different diets. Although the effect of dietary changes on the exocrine pancreas has been described in several animals, little, apart from the effect of malnutrition, has been reported for the endocrine pancreas. Reported here are pancreatic endocrine cell distributions in monkeys on a standard diet (n = 3) compared with monkeys on an atherogenic diet (n = 3). Quantitation of immunolabelled pancreatic endocrine cell types revealed a significant 80% increase in A (glucagon) cell volume in monkeys on an atherogenic diet concomitant with a significant reduction in B (insulin) cell volume to approximately 60% of normal. This reflects a pattern of events that occurs in non-insulin dependent diabetes. An accompanying reduction in PP (pancreatic polypeptide) cell volumes supports our hypothesis that altering A and PP cell volumes could reflect differential gene expression in those cells in the adult in which glucagon and PP are co-localized.
J Louw; C Woodroof; J Seier; S A Wolfe-Coote
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of medical primatology     Volume:  26     ISSN:  0047-2565     ISO Abbreviation:  J. Med. Primatol.     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-02-20     Completed Date:  1998-02-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0320626     Medline TA:  J Med Primatol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  307-11     Citation Subset:  IM    
Experimental Biology Programme, MRC, Tygerberg, South Africa.
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MeSH Terms
Cercopithecus / physiology*
Diabetes Mellitus, Type 2 / etiology,  genetics,  veterinary*
Dietary Fats*
Gene Expression
Glucagon / genetics,  physiology
Insulin / physiology
Islets of Langerhans / cytology*,  physiology
Pancreatic Polypeptide / genetics,  physiology
Somatostatin / physiology
Reg. No./Substance:
0/Dietary Fats; 11061-68-0/Insulin; 51110-01-1/Somatostatin; 59763-91-6/Pancreatic Polypeptide; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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