Document Detail

The effect of diclofenac and paracetamol on pregnancy and implantation rates in infertile women undergoing IVF treatment.
MedLine Citation:
PMID:  17130031     Owner:  NLM     Status:  MEDLINE    
We set out to assess the effect of diclofenac on implantation rates, when administered as analgesia following transvaginal oocyte recovery. This was a prospective study of infertile women undergoing IVF treatment in a University Hospital. Subjects (n = 74) were divided in two groups (A and B). Group A (n = 38) received 1 g paracetamol and 100 mg diclofenac and group B (n = 36) received 1 g paracetamol only. All the medication was administered rectally immediately after the oocyte retrieval. Pregnancy and implantation rates were compared between group A and B using the chi2 test. In groups A and B, the implantation rates were 12.4% and 9.6% (p = 0.5) and the pregnancy rates were 28.9% and 19.4%, respectively (p = 0.67). Neither pregnancy nor implantation rates differed significantly between the two groups. Administration of diclofenac to patients at the time of egg collection does not appear to affect implantation or pregnancy rates, while it could be effective in reducing discomfort and pain associated with oocyte retrieval.
V Akande; A Garas; D Cahill
Publication Detail:
Type:  Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology     Volume:  26     ISSN:  0144-3615     ISO Abbreviation:  J Obstet Gynaecol     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-11-28     Completed Date:  2007-03-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309140     Medline TA:  J Obstet Gynaecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  785-7     Citation Subset:  IM    
Centre for Reproductive Medicine, University of Bristol, Bristol, UK.
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MeSH Terms
Acetaminophen / pharmacology*
Analgesics, Non-Narcotic / pharmacology*
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
Diclofenac / pharmacology*
Embryo Implantation / drug effects*
Fertilization in Vitro*
Infertility, Female / therapy*
Reg. No./Substance:
0/Analgesics, Non-Narcotic; 0/Anti-Inflammatory Agents, Non-Steroidal; 103-90-2/Acetaminophen; 15307-86-5/Diclofenac

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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