Document Detail


The effect of diabetes mellitus on histopathological changes in the denture-supporting tissues under continuous mechanical pressure in rat.
MedLine Citation:
PMID:  10080328     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The histopathological changes in denture-supporting tissues of streptozotocin-induced diabetes mellitus rat were studied in relation to continuous mechanical pressure exerted through an experimental denture base. The experimental dentures were designed to load continuous mechanical pressures (3.4, 1.5 or 0.5 kPa) to the hard palate of the molar region of a rat. From the results of this study, the following conclusions were drawn: the streptozotocin-induced diabetic condition (1) tended to prolong the appearance period of a shortened epithelial ridge, and weakened the phenomenon, (2) reduced the appearance period and severity of the compression of epithelium, (3) delayed the time of manifestation of the proliferative change in the recovery process of the shortened epithelial ridge, and weakened the phenomenon, (4) prolonged the appearance period of the compressed lamina propria mucosae, and enhanced the phenomenon, (5) reduced the number of osteoclasts, (6) lowered the threshold for induction of the osteoclastic bone resorption to between 1.5 and 0.5 kPa, (7) inhibited the appearance of osteoblast which follows the disappearance of osteoclasts, (8) did not induce any inflammatory change, and (9) tended to enhance the longitudinal change of the continuous mechanical pressure. The histopathological changes in the denture-supporting tissues of the streptozotocin-induced diabetes mellitus rat related highly to the longitudinal change of the continuous mechanical pressure exerted through the denture base. From the results of this study, it was suggested that the streptozotocin-induced diabetic condition lowers the tolerance of the denture-supporting tissues to continuous mechanical pressure.
Authors:
S Mori; T Sato; T Hara; H Shirai; Y Maruo; S Minagi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of oral rehabilitation     Volume:  26     ISSN:  0305-182X     ISO Abbreviation:  J Oral Rehabil     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-05-03     Completed Date:  1999-05-03     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0433604     Medline TA:  J Oral Rehabil     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  80-90     Citation Subset:  D; IM    
Affiliation:
Department of Removable Prosthodontics, Okayama University Dental School, Okayama City, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Basement Membrane / pathology,  physiopathology
Bone Resorption / pathology,  physiopathology
Cell Division
Denture Bases*
Diabetes Mellitus, Experimental / pathology*,  physiopathology
Epithelium / pathology,  physiopathology
Longitudinal Studies
Male
Mouth Mucosa / pathology,  physiopathology
Osteoblasts / pathology,  physiology
Osteoclasts / pathology,  physiology
Palate / pathology,  physiopathology
Periodontium / pathology*,  physiopathology
Pressure
Rats
Rats, Wistar
Streptozocin
Stress, Mechanical
Chemical
Reg. No./Substance:
18883-66-4/Streptozocin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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