Document Detail


The effect of dexmedetomidine on the balance of myocardial energy requirement and oxygen supply and demand.
MedLine Citation:
PMID:  8623959     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of the alpha(2)-adrenergic agonist dexmedetomidine on the balance between myocardial energy requirement and oxygen supply and demand was investigated in 16 open-chest dogs anesthetized with either chloralose/urethane (CU) or fentanyl/halothane (FH). Myocardial energy requirement (estimated from the pressure work index), blood flow and its transmural distribution (radioactive microspheres), as well as myocardial oxygen and lactate extraction, were measured before and after administration of dexmedetomidine in doses ranging from 0.1 to 10 micrograms/kg intravenously. Under CU anesthesia, dexmedetomidine decreased heart rate, arterial blood pressure, and cardiac output. During FH anesthesia, dexmedetomidine reduced heart rate and cardiac output whereas arterial blood pressure increased. Dexmedetomidine decreased myocardial energy requirement only during CU anesthesia; myocardial oxygen supply and demand decreased in parallel. At the (large) dose of 10 micrograms/kg, myocardial oxygen extraction increased during both types of anesthesia. Dexmedetomidine >/= 1 microgram/kg increased endocardial/epicardial blood flow ratio during FH anesthesia. These data indicate that dexmedetomidine >/= 1 microgram/kg reduces myocardial energy requirements, especially when baseline heart rate and blood pressure are increased. Dexmedetomidine preserves endocardial perfusion and reduces oxygen demand in parallel with oxygen supply and energy requirements.
Authors:
C J Lawrence; F W Prinzen; S de Lange
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  82     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-06-14     Completed Date:  1996-06-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  544-50     Citation Subset:  AIM; IM    
Affiliation:
Department of Anesthesiology, University Hospital of Maastricht, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Agonists / pharmacology*
Anesthetics, Inhalation / administration & dosage
Anesthetics, Intravenous / administration & dosage
Animals
Blood Pressure / drug effects
Cardiac Output / drug effects
Chloralose / administration & dosage
Coronary Circulation / drug effects
Dogs
Energy Metabolism / drug effects*
Female
Fentanyl / administration & dosage
Halothane / administration & dosage
Heart / drug effects*
Heart Rate / drug effects
Imidazoles / pharmacology*
Lactates / blood
Male
Medetomidine
Myocardium / metabolism*
Oxygen / blood*
Oxygen Consumption / drug effects*
Stroke Volume / drug effects
Urethane / administration & dosage
Vascular Resistance / drug effects
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Anesthetics, Inhalation; 0/Anesthetics, Intravenous; 0/Imidazoles; 0/Lactates; 151-67-7/Halothane; 15879-93-3/Chloralose; 437-38-7/Fentanyl; 51-79-6/Urethane; 7782-44-7/Oxygen; 86347-14-0/Medetomidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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