Document Detail

The effect of the destruction of the caudate-putamen on the development of amygdaloid kindling and kindled seizures.
MedLine Citation:
PMID:  12365597     Owner:  NLM     Status:  MEDLINE    
To elucidate the possible roles of the caudate-putamen (CP) on the development of amygdala (AM) kindling and AM-kindled seizures, the bilateral CP were destroyed by intra-CP injection of ibotenic acid (0.5 or 1.0 microg per side) before the AM kindling or after completion of the AM kindling. Prior destruction of the CP, especially by 0.5 microg ibotenic acid injection, caused a significant delay in seizure development. However, after completion of the AM kindling, bilateral destruction of the CP significantly suppressed AM-kindled seizures in proportion to lesion size, however, all animals reached a stage 5 seizure by additional stimulations and established AM kindling. These findings suggest that the intact CP modulates the development of the AM kindling and the generalization and/or expression of the kindled AM seizures, and that the CP plays an important role in the generalization and/or expression of the kindled AM seizures.
Yasuhito Yamada; Norio Mori; Katsuaki Suzuki; Kouichi Osonoe; Minako Osonoe; Syuzo Hoshino; Shin-ichi Niwa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fukushima journal of medical science     Volume:  48     ISSN:  0016-2590     ISO Abbreviation:  Fukushima J Med Sci     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-10-07     Completed Date:  2002-11-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374626     Medline TA:  Fukushima J Med Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  39-50     Citation Subset:  IM    
Department of Neuropsychiatry, School of Medicine, Fukushima Medical University School of Medicine, Japan.
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MeSH Terms
Amygdala / physiopathology
Caudate Nucleus / injuries*,  physiopathology
Ibotenic Acid / toxicity
Kindling, Neurologic / physiology*
Putamen / injuries*,  physiopathology
Rats, Wistar
Seizures / etiology*,  physiopathology
Reg. No./Substance:
2552-55-8/Ibotenic Acid

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