| The effect of delta-aminolaevulinic acid on the high affinity uptake of aspartic acid by rat brain synaptosomes. | |
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MedLine Citation:
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PMID: 6526266 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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delta-Aminolaevulinic (delta-ALA) acid is an analogue of GABA, glutamate and aspartate. High affinity GABA uptake by synaptosomes is inhibited by delta-ALA in a competitive fashion at high concentrations (greater than 0.5 mM). Glutamate uptake is inhibited in a non-competitive fashion at all delta-ALA concentrations (0.05-2.0 mM). High affinity aspartate uptake is inhibited in a non-competitive fashion at high concentration (greater than 1.0 mM) but exhibits a curve which resembles that for the inhibition of GABA uptake. The different interactions between delta-ALA, glutamate and aspartate may be evidence for a separate transport system for aspartate. |
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Authors:
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J L McLoughlin; R C Cantrill |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: General pharmacology Volume: 15 ISSN: 0306-3623 ISO Abbreviation: Gen. Pharmacol. Publication Date: 1984 |
Date Detail:
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Created Date: 1985-04-18 Completed Date: 1985-04-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7602417 Medline TA: Gen Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 553-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aminolevulinic Acid
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pharmacology* Animals Aspartic Acid / metabolism* Brain / drug effects, metabolism* Glutamates / metabolism Levulinic Acids / pharmacology* Rats Synaptosomes / drug effects, metabolism* gamma-Aminobutyric Acid / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Glutamates; 0/Levulinic Acids; 106-60-5/Aminolevulinic Acid; 56-12-2/gamma-Aminobutyric Acid; 56-84-8/Aspartic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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