Document Detail


The effect of delta-aminolaevulinic acid on the high affinity uptake of aspartic acid by rat brain synaptosomes.
MedLine Citation:
PMID:  6526266     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
delta-Aminolaevulinic (delta-ALA) acid is an analogue of GABA, glutamate and aspartate. High affinity GABA uptake by synaptosomes is inhibited by delta-ALA in a competitive fashion at high concentrations (greater than 0.5 mM). Glutamate uptake is inhibited in a non-competitive fashion at all delta-ALA concentrations (0.05-2.0 mM). High affinity aspartate uptake is inhibited in a non-competitive fashion at high concentration (greater than 1.0 mM) but exhibits a curve which resembles that for the inhibition of GABA uptake. The different interactions between delta-ALA, glutamate and aspartate may be evidence for a separate transport system for aspartate.
Authors:
J L McLoughlin; R C Cantrill
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  General pharmacology     Volume:  15     ISSN:  0306-3623     ISO Abbreviation:  Gen. Pharmacol.     Publication Date:  1984  
Date Detail:
Created Date:  1985-04-18     Completed Date:  1985-04-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7602417     Medline TA:  Gen Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  553-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aminolevulinic Acid / pharmacology*
Animals
Aspartic Acid / metabolism*
Brain / drug effects,  metabolism*
Glutamates / metabolism
Levulinic Acids / pharmacology*
Rats
Synaptosomes / drug effects,  metabolism*
gamma-Aminobutyric Acid / metabolism
Chemical
Reg. No./Substance:
0/Glutamates; 0/Levulinic Acids; 106-60-5/Aminolevulinic Acid; 56-12-2/gamma-Aminobutyric Acid; 56-84-8/Aspartic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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