Document Detail

The effect of dehydroepiandrosterone on Zucker rats selected for fat food preference.
MedLine Citation:
PMID:  11110996     Owner:  NLM     Status:  MEDLINE    
When allowed to select between macronutrients in a 1-h-a-day meal paradigm, Zucker rats consume 20-80% of their total caloric intake as fat. If they receive an intraperitoneal injection of DHEA 2 h before such a test meal, they consume fewer total calories. The magnitude of this effect on each macronutrient depends upon the animal's initial preference for fat; the higher the initial fat preference, the more profound is the decrease in caloric intake and the more pronounced the effect on fat consumption. Doses as low as 25 mg DHEA/kg body weight are effective. Lean Zucker rats that prefer to consume a high-fat diet have higher epinephrine and dopamine levels in select regions of the hypothalamus known to control food intake. Administration of DHEA to such animals 2 h before decapitation reduces the content of norepinephrine and these monoamines to levels that mimic the values found in the low-fat-preferring animals. It is hypothesized that exogenous DHEA causes the acute release of norepinephrine, epinephrine, and dopamine in select regions of the hypothalamus, and this release causes a decrease in food intake, particularly fat.
J Pham; J Porter; D Svec; C Eiswirth; F Svec
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Physiology & behavior     Volume:  70     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2001-01-02     Completed Date:  2001-02-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  431-41     Citation Subset:  IM    
Obesity Research Program, Section of Endocrinology, Department of Medicine, Louisiana State University Health Sciences Center, 1542 Tulane Avenue, New Orleans, LA 70112, USA.
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MeSH Terms
Body Weight / drug effects
Corticosterone / administration & dosage
Dehydroepiandrosterone / administration & dosage*,  metabolism
Dietary Carbohydrates / metabolism
Dietary Fats / metabolism*
Dietary Proteins / metabolism
Dose-Response Relationship, Drug
Drug Administration Schedule
Energy Intake / drug effects
Food Preferences / drug effects*,  physiology
Hypothalamus / drug effects,  metabolism
Injections, Intraperitoneal
Neurotransmitter Agents / metabolism
Obesity / metabolism
Rats, Zucker
Thinness / metabolism
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Dietary Fats; 0/Dietary Proteins; 0/Neurotransmitter Agents; 50-22-6/Corticosterone; 53-43-0/Dehydroepiandrosterone

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