| The effect of degenerated neuron density of petrosal ganglion on the development of blood pressure variabilities after subarachnoid hemorrhage in a rabbit model: an experimental study. | |
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MedLine Citation:
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PMID: 22194117 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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AIM: The aim of this study was to determine the relationship between ischemic neurodegeneration, of the petrosal ganglion of the glossopharyngeal nerve, and BP fluctuations, after subarachnoid hemorrhage (SAH). MATERIAL and METHODS: Twenty-four rabbits had their blood pressure and heart rhythms studied daily over 20 days. Then, the histopathology of the petrosal ganglion was examined in all animals. Normal and apoptotic neuron density of the petrosal ganglion and blood pressure values were compared statistically. RESULTS: Mean total volume of the petrosal ganglia was calculated as 0.9±0.34/mm3. BP level of control group was 96.1±2.1mmHg; 116.5±4mmHg of mild hypertension (HT) group and 128.1±3.6mmHg in the severe HT group. When the groups were compared to each other they were significantly different. The level of normal-apoptotic neuron in control group was 11240±802/mm < sup > 3 < /sup > -40±6.3/mm < sup > 3 < /sup > ; 9730±148.7/mm < sup > 3 < /sup > - 1560±256.2/mm < sup > 3 < /sup > in the mild HT group and 6870±378.8/mm < sup > 3 < /sup > -4240±628.2/mm < sup > 3 < /sup > in the severe HT group. When the groups were compared to each other there was significantly difference. CONCLUSION: Blood pressure variability observed in this study may be explained by ischemic neurodegeneration of petrosal ganglia caused by SAH. The results of this study suggest that petrosal ganglion ischemia has potential implications for the development of hypertension. These findings suggest that new treatment strategies should be considered for the treatment of SAH. |
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Authors:
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Ahmet Murat Musluman; Mehmet Dumlu Aydin; Adem Yilmaz; Tufan Cansever; Ayhan Kanat; Cemal Gundogdu; Zeynep Cakir; Mucahit Emet; Nesrin Gursan; Nazan Aydin; Bunyamin Unal |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Turkish neurosurgery Volume: 21 ISSN: 1019-5149 ISO Abbreviation: Turk Neurosurg Publication Date: 2011 |
Date Detail:
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Created Date: 2011-12-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423821 Medline TA: Turk Neurosurg Country: Turkey |
Other Details:
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Languages: eng Pagination: 559-66 Citation Subset: IM |
Affiliation:
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Sisli Research and Education Hospital, Department of Neurosurgery, Istanbul Turkey. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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