Document Detail

The effect of cysteine analogues on the excretion of urinary sulphate in the rat following cysteine administration.
MedLine Citation:
PMID:  15283299     Owner:  NLM     Status:  MEDLINE    
A major pathway for the production of sulphate within the mammalian body is known to be via the oxidative degradation of the sulphur moiety within the amino acid, L-cysteine. The ability of two structurally similar sulphur-containing drugs, the anti-rheumatic agent, D-penicillamine, and the mucoactive compound, S-carboxymethyl-L-cysteine, to interfere with this sulphate production was investigated. Co-administration to the male rat of D-penicillamine (p.o.) and S-carboxymethyl-L-cysteine (p.o.) with [35S]-L-cysteine (i.p.) led to a significant decrease in the subsequent urinary elimination of inorganic sulphate whilst having no measurable effect on organic sulphate excretion. The co-administration of L-valine, an amino acid not containing sulphur, had no effect. It is not known where, within the complex sequence of events surrounding the degradation of cysteine to sulphate, that D-penicillamine or S-carboxymethyl-L-cysteine may interact.
E S Roopnarinsingh; G B Steventon; R M Harris; R H Waring; S C Mitchell
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Drug metabolism and drug interactions     Volume:  20     ISSN:  0792-5077     ISO Abbreviation:  Drug Metabol Drug Interact     Publication Date:  2004  
Date Detail:
Created Date:  2004-07-30     Completed Date:  2004-09-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8904736     Medline TA:  Drug Metabol Drug Interact     Country:  England    
Other Details:
Languages:  eng     Pagination:  1-10     Citation Subset:  IM    
Section of Biological Chemistry, Division of Biomedical Sciences, Faculty of Medicine, Imperial College London, UK.
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MeSH Terms
Anti-Infective Agents, Local / administration & dosage*,  chemistry
Antirheumatic Agents / administration & dosage*,  chemistry
Carbocysteine / administration & dosage*,  chemistry
Cysteine / administration & dosage,  analogs & derivatives,  chemistry
Drug Interactions
Injections, Intraperitoneal
Models, Chemical
Penicillamine / administration & dosage*,  chemistry
Rats, Wistar
Sulfates / urine*
Valine / administration & dosage,  chemistry
Reg. No./Substance:
0/Anti-Infective Agents, Local; 0/Antirheumatic Agents; 0/Sulfates; 2387-59-9/Carbocysteine; 52-67-5/Penicillamine; 52-90-4/Cysteine; 7004-03-7/Valine

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