| The effect of cysteine analogues on the excretion of urinary sulphate in the rat following cysteine administration. | |
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MedLine Citation:
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PMID: 15283299 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A major pathway for the production of sulphate within the mammalian body is known to be via the oxidative degradation of the sulphur moiety within the amino acid, L-cysteine. The ability of two structurally similar sulphur-containing drugs, the anti-rheumatic agent, D-penicillamine, and the mucoactive compound, S-carboxymethyl-L-cysteine, to interfere with this sulphate production was investigated. Co-administration to the male rat of D-penicillamine (p.o.) and S-carboxymethyl-L-cysteine (p.o.) with [35S]-L-cysteine (i.p.) led to a significant decrease in the subsequent urinary elimination of inorganic sulphate whilst having no measurable effect on organic sulphate excretion. The co-administration of L-valine, an amino acid not containing sulphur, had no effect. It is not known where, within the complex sequence of events surrounding the degradation of cysteine to sulphate, that D-penicillamine or S-carboxymethyl-L-cysteine may interact. |
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Authors:
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E S Roopnarinsingh; G B Steventon; R M Harris; R H Waring; S C Mitchell |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Drug metabolism and drug interactions Volume: 20 ISSN: 0792-5077 ISO Abbreviation: Drug Metabol Drug Interact Publication Date: 2004 |
Date Detail:
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Created Date: 2004-07-30 Completed Date: 2004-09-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904736 Medline TA: Drug Metabol Drug Interact Country: England |
Other Details:
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Languages: eng Pagination: 1-10 Citation Subset: IM |
Affiliation:
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Section of Biological Chemistry, Division of Biomedical Sciences, Faculty of Medicine, Imperial College London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Infective Agents, Local / administration & dosage*, chemistry Antirheumatic Agents / administration & dosage*, chemistry Carbocysteine / administration & dosage*, chemistry Cysteine / administration & dosage, analogs & derivatives, chemistry Drug Interactions Injections, Intraperitoneal Male Models, Chemical Penicillamine / administration & dosage*, chemistry Rats Rats, Wistar Sulfates / urine* Valine / administration & dosage, chemistry |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents, Local; 0/Antirheumatic Agents; 0/Sulfates; 2387-59-9/Carbocysteine; 52-67-5/Penicillamine; 52-90-4/Cysteine; 7004-03-7/Valine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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