Document Detail


The effect of cyproterone acetate on the adrenal of the male hamster.
MedLine Citation:
PMID:  946709     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Administration for different doses of cyproterone acetate (CPA) to male hamsters for 5 weeks slows down the growth of the adrenals and the increase in body weight. This effect is still present 4 weeks after cessation of CPA treatment, though some recovery can be seen. Histological and histometrical evaluations confirm an atrophy of the adrenal, particularly in the zona fasciculata and in higher doses also in the zona reticularis. After operative castration it is the zona reticularis which shows the most marked atrophic changes. It is therefore concluded, that CPA possesses besides its anti-androgenic properties an inhibiting corticoid-like effect on the adreno-pituitary feed-back mechanism.
Authors:
G Zieger; B Lux; B Kubatsch
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta endocrinologica     Volume:  82     ISSN:  0001-5598     ISO Abbreviation:  Acta Endocrinol.     Publication Date:  1976 May 
Date Detail:
Created Date:  1976-07-06     Completed Date:  1976-07-06     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0370312     Medline TA:  Acta Endocrinol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  127-33     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adrenal Glands / drug effects*
Animals
Body Weight / drug effects
Cricetinae
Cyproterone / pharmacology*
Feedback
Male
Organ Size / drug effects
Pituitary-Adrenal System / drug effects
Chemical
Reg. No./Substance:
2098-66-0/Cyproterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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