Document Detail

The effect of cyclical hormonal changes on erythrocyte electrolyte transport mechanisms.
MedLine Citation:
PMID:  3004798     Owner:  NLM     Status:  MEDLINE    
Electrolyte transport characteristics were examined in erythrocytes from 13 normal men and from two groups of women: taking combined oral contraceptive preparations (O/C, n = 10), and ovulatory women (non-O/C, n = 10) pre- and post-ovulation, at the same time intervals (days 7-10 and days 15-18) during a menstrual cycle. With rubidium (86Rb+) used as a potassium analogue, co-transport (ouabain-resistant, frusemide-sensitive 86Rb+ influx) values were found to be lowest in non-O/C women (28 +/- SE 2.5 nmol h-1 10(-9) cells) and highest in men (56 +/- 5.7, P less than 0.001), with results between the two in women taking O/C (42 +/- 4.2, P less than 0.05 vs men, P less than 0.01 vs non-O/C). Passive 86Rb leak (frusemide-and ouabain-resistant) was significantly lower in men (13 +/- 1.6 nmol h-1 10(-9) cells) than in both groups of women (non-O/C 29 +/- 1.8, P less than 0.001; O/C 25 +/- 1.2, P less than 0.001). There was no cyclical variation within either group of women. Maximum ouabain binding (number of NA+,K+-ATPase units) was the same in all groups. Na+,K+-ATPase activity, as determined by ouabain-sensitive 86Rb influx, was the same in men and non-O/C groups, but was significantly suppressed in O/C compared with both men (P less than 0.01) and non-O/C women (P less than 0.05). The differences found were not due to alterations in either progesterone or aldosterone, but could represent an androgenic effect in vivo of the 19-nortestosterone derivatives in combined oral contraceptive preparations.
E D Gallery; C Bean; R Grigg; D M Saunders
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  70     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1986-04-17     Completed Date:  1986-04-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  263-9     Citation Subset:  IM    
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MeSH Terms
Aldosterone / metabolism
Biological Transport / drug effects
Contraceptives, Oral, Combined / pharmacology*
Erythrocytes / metabolism*
Ethinyl Estradiol / pharmacology
Menstrual Cycle
Norethindrone / pharmacology
Potassium / metabolism
Renin / blood
Sodium / metabolism
Sodium-Potassium-Exchanging ATPase / metabolism
Reg. No./Substance:
0/Contraceptives, Oral, Combined; 52-39-1/Aldosterone; 57-63-6/Ethinyl Estradiol; 68-22-4/Norethindrone; 7440-09-7/Potassium; 7440-23-5/Sodium; EC; EC ATPase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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