Document Detail

The effect of cryopreservation in prevention of ovarian hyperstimulation syndrome.
MedLine Citation:
PMID:  7612517     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the effect of elective cryopreservation of all embryos in the prevention of severe ovarian hyperstimulation syndrome in women at increased risk, following superovulation for in vitro fertilisation. DESIGN: Three hundred and ninety women undergoing superovulation for in vitro fertilisation between September 1991 and December 1992. SETTING: University Infertility Clinic, Helsinki, Finland. INTERVENTIONS: Twenty-three women were considered to have an increased risk of developing ovarian hyperstimulation syndrome. They were characterised by more than 20 retrieved oocytes and/or by serum oestradiol levels exceeding 10,000 pmol/l on the day of administration of human chorionic gonadotrophin. Instead of cancelling the cycle the oocytes were harvested and fertilised, and all good quality embryos were cryopreserved. The embryos were thawed and replaced during subsequent natural cycles. MAIN OUTCOME MEASURES: Occurrence of ovarian hyperstimulation syndrome and pregnancy rate. RESULTS: One out of the 23 patients at increased risk developed a moderate degree ovarian hyperstimulation syndrome, while the others had only mild symptoms. Two of the remaining 367 women with no risk developed ovarian hyperstimulation syndrome, both during early pregnancy. Among the 23 patients at increased risk there have been 15 clinical pregnancies after transfer of two to three frozen-thawed embryos in natural cycles, with a 32.6% pregnancy rate. CONCLUSIONS: Withholding embryo replacement and elective cryopreservation of the embryos is effective in preventing severe ovarian hyperstimulation syndrome. After subsequent replacement in natural cycles the implantation rate per embryo is good (22.7%).
A Tiitinen; L M Husa; M Tulppala; N Simberg; M Seppälä
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  102     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-08-22     Completed Date:  1995-08-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  326-9     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, Finland.
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MeSH Terms
Fertilization in Vitro / adverse effects*,  methods
Ovarian Hyperstimulation Syndrome / prevention & control*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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