| The effect of cromoglycate on time-dependent histamine and serotonin concentrations in stored blood products. | |
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MedLine Citation:
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PMID: 16516555 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Biogenic amines, having vascular and inflammatory effects, are accepted as a potential threat for some non-hemolytic transfusion reactions. The aim of this study was to investigate time-dependent histamine/serotonin levels in stored blood products and to see whether cromoglycate has any effect on these mediators. Either for platelet or whole blood, 10-fold concentrations of cromoglycate (1 microg ml(-1), 10 microg ml(-1), 100 microg ml(-1)) with controls prepared as pairs of replicate bags collected from two healthy subjects, separately. By using enzyme immunoassay, histamine and serotonin levels were determined in platelet or blood replicates. Histamine levels increased significantly with time but serotonin remained unchanged during the storage of platelet or blood specimens. Cromoglycate had no effect on these biogenic amines except an increase of serotonin in whole blood specimens containing 100 microg ml(-1) of it. So, cromoglycate cannot protect blood products against rising levels of histamine or serotonin. |
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Authors:
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Kamuran Konca; E Naci Tiftik; Gönül Aslan; Arzu Kanik; Atilla Yalçin |
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Publication Detail:
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Type: Journal Article Date: 2006-03-03 |
Journal Detail:
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Title: Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis Volume: 34 ISSN: 1473-0502 ISO Abbreviation: Transfus. Apher. Sci. Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-04-17 Completed Date: 2006-07-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101095653 Medline TA: Transfus Apher Sci Country: England |
Other Details:
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Languages: eng Pagination: 193-8 Citation Subset: T |
Affiliation:
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Mersin University, Faculty of Medicine, Department of Internal Medicine, Clinical Immunology Section, Mersin, Turkey. kamukon@msn.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Blood Donors Blood Preservation / methods* Cromolyn Sodium / pharmacology* Histamine / blood* Humans Kinetics Male Serotonin / blood* |
| Chemical | |
Reg. No./Substance:
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15826-37-6/Cromolyn Sodium; 50-67-9/Serotonin; 51-45-6/Histamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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