Document Detail

The effect of creatine supplementation on myocardial function, mitochondrial respiration and susceptibility to ischemia/reperfusion injury in sedentary and exercised rats.
MedLine Citation:
PMID:  22741552     Owner:  NLM     Status:  Publisher    
AIM: To investigate the effects of dietary creatine supplementation alone and in combination with exercise on basal cardiac function, susceptibility to ischemia/reperfusion injury and mitochondrial oxidative function. METHODS: Male Wistar rats were swim-trained for 8 weeks, 5 days/week. Hearts were excised and either freeze-clamped for biochemical analysis or perfused on the isolated heart perfusion system to assess function and ischemia/reperfusion tolerance. Mechanical function was documented in working heart and retrograde mode. The left coronary artery was ligated and infarct size determined. Mitochondrial oxidative capacity was quantified. RESULTS: Aortic output recovery of hearts from the sedentary controls (CSed) were significantly higher than those from creatine supplemented sedentary (CrSed), creatine supplemented exercised (CrEx) as well as control exercised (CEx) groups. Ischemic contracture of hearts from CrEx was significantly higher than that of CSed. There were no differences in infarct size and mitochondrial oxygen consumption. CONCLUSION: This study suggests that creatine supplementation has no effects on basal cardiac function but reduces myocardial tolerance to ischemia in hearts from exercise trained animals by increasing the ischemic contracture and decreasing reperfusion aortic output. Exercise training alone also significantly decreased aortic output recovery. However, the exact mechanisms for these adverse myocardial effects are unknown and need further investigation. © 2012 The Authors Acta Physiologica © 2012 Scandinavian Physiological Society.
Ingrid Webster; Ef Du Toit; Barbara Huisamen; A Lochner
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-29
Journal Detail:
Title:  Acta physiologica (Oxford, England)     Volume:  -     ISSN:  1748-1716     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101262545     Medline TA:  Acta Physiol (Oxf)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors Acta Physiologica © 2012 Scandinavian Physiological Society.
University of Stellenbosch, Medical Physiology.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Social economic factors and malaria transmission in Lower Moshi, northern Tanzania.
Next Document:  Precursor directed biosynthesis of an orthogonally functional erythromycin analogue: selectivity in ...