Document Detail


The effect of the corticosteroid hormone cortexolone on the metabolites produced during phenanthrene biotransformation in Cunninghamella elegans.
MedLine Citation:
PMID:  16504243     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The metabolism of phenanthrene and the mammalian corticosteroid hormone cortexolone by the fungus Cunninghamella elegans was studied. The amounts of the cortexolone transformation products, cortisol and epicortisol, were affected by the presence of phenanthrene. Approximately 40% more cortisol was produced by C. elegans in cultures with phenanthrene. In contrast, epicortisol formation decreased. C. elegans transformed phenanthrene to phenanthrene trans-1,2-,3,4-, and 9,10-dihydrodiols, phenols, diphenols (diols) and glucoside conjugates of 1-, 2-, 3-, 4-, and 9-phenanthrols. Almost all of the phenanthrene initially added was metabolized to ethyl acetate extractable metabolites. In the mycelia and culture medium extracts, phenanthrol glucosides represented 80% and 94% of the total metabolites, respectively. The major metabolite was the glucoside conjugate of 1-phenanthrol. The presence of cortexolone affected the biodegradation of phenanthrene by decreasing the amounts of phenanthrene metabolites compared to control cultures.
Authors:
Katarzyna Lisowska; Jerzy Długoński; James P Freeman; Carl E Cerniglia
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-02-28
Journal Detail:
Title:  Chemosphere     Volume:  64     ISSN:  0045-6535     ISO Abbreviation:  Chemosphere     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-24     Completed Date:  2006-10-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0320657     Medline TA:  Chemosphere     Country:  England    
Other Details:
Languages:  eng     Pagination:  1499-506     Citation Subset:  IM    
Affiliation:
Department of Industrial Microbiology and Biotechnology, University of Łódź, Banacha 12/16, 90-237 Łódź, Poland. katalis@biol.uni.lodz.pl
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MeSH Terms
Descriptor/Qualifier:
Biodegradation, Environmental
Biotransformation
Cortodoxone / pharmacokinetics,  pharmacology*
Cunninghamella / drug effects,  growth & development,  metabolism*
Environmental Pollutants / analysis,  pharmacokinetics*
Gas Chromatography-Mass Spectrometry
Phenanthrenes / analysis,  pharmacokinetics*
Spectrometry, Mass, Electrospray Ionization
Chemical
Reg. No./Substance:
0/Environmental Pollutants; 0/Phenanthrenes; 152-58-9/Cortodoxone; 85-01-8/phenanthrene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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