| The effect of the corticosteroid hormone cortexolone on the metabolites produced during phenanthrene biotransformation in Cunninghamella elegans. | |
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MedLine Citation:
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PMID: 16504243 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The metabolism of phenanthrene and the mammalian corticosteroid hormone cortexolone by the fungus Cunninghamella elegans was studied. The amounts of the cortexolone transformation products, cortisol and epicortisol, were affected by the presence of phenanthrene. Approximately 40% more cortisol was produced by C. elegans in cultures with phenanthrene. In contrast, epicortisol formation decreased. C. elegans transformed phenanthrene to phenanthrene trans-1,2-,3,4-, and 9,10-dihydrodiols, phenols, diphenols (diols) and glucoside conjugates of 1-, 2-, 3-, 4-, and 9-phenanthrols. Almost all of the phenanthrene initially added was metabolized to ethyl acetate extractable metabolites. In the mycelia and culture medium extracts, phenanthrol glucosides represented 80% and 94% of the total metabolites, respectively. The major metabolite was the glucoside conjugate of 1-phenanthrol. The presence of cortexolone affected the biodegradation of phenanthrene by decreasing the amounts of phenanthrene metabolites compared to control cultures. |
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Authors:
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Katarzyna Lisowska; Jerzy Długoński; James P Freeman; Carl E Cerniglia |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-02-28 |
Journal Detail:
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Title: Chemosphere Volume: 64 ISSN: 0045-6535 ISO Abbreviation: Chemosphere Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-07-24 Completed Date: 2006-10-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0320657 Medline TA: Chemosphere Country: England |
Other Details:
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Languages: eng Pagination: 1499-506 Citation Subset: IM |
Affiliation:
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Department of Industrial Microbiology and Biotechnology, University of Łódź, Banacha 12/16, 90-237 Łódź, Poland. katalis@biol.uni.lodz.pl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biodegradation, Environmental Biotransformation Cortodoxone / pharmacokinetics, pharmacology* Cunninghamella / drug effects, growth & development, metabolism* Environmental Pollutants / analysis, pharmacokinetics* Gas Chromatography-Mass Spectrometry Phenanthrenes / analysis, pharmacokinetics* Spectrometry, Mass, Electrospray Ionization |
| Chemical | |
Reg. No./Substance:
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0/Environmental Pollutants; 0/Phenanthrenes; 152-58-9/Cortodoxone; 85-01-8/phenanthrene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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