Document Detail

The effect of conventional and mini-invasive cardiopulmonary bypass on neutrophil activation in patients undergoing coronary artery bypass grafting.
MedLine Citation:
PMID:  22529517     Owner:  NLM     Status:  MEDLINE    
Interleukin-10 (IL-10) is considered to be a cytokine with potent anti-inflammatory properties, which have been previously linked to increased incidence of sepsis. The level of IL-10 is elevated by cardiac surgery when cardiopulmonary bypass (CPB) and methylprednisolone are used. In our study, we compare the level of IL-10, IL-10 Receptor (IL-10R), and percentage of neutrophils between two groups of cardiac surgical patients undergoing Coronary Artery Bypass Grafting, both of which were not given methylprednisolone. The first group was operated with conventional CPB, while the second group was operated with minimally invasive CPB (mini-CPB). We detected enhanced level of IL-10 during surgery and at the end of surgery in both groups of patients. While no correlation between IL-10 and IL10R was found, IL-10 was positively correlated with increased percentage of neutrophils at the time points when the level of IL-10 peaked.
Martina Kolackova; Jan Krejsek; Vladimir Svitek; Pavel Kunes; Jiri Mandak; Zdenka Holubcova; Vladimir Lonsky
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-02-19
Journal Detail:
Title:  Mediators of inflammation     Volume:  2012     ISSN:  1466-1861     ISO Abbreviation:  Mediators Inflamm.     Publication Date:  2012  
Date Detail:
Created Date:  2012-04-24     Completed Date:  2012-09-20     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  9209001     Medline TA:  Mediators Inflamm     Country:  United States    
Other Details:
Languages:  eng     Pagination:  152895     Citation Subset:  IM    
Department of Clinical Immunology, Faculty of Medicine, Charles University, 50005 Hradec Kralove, Czech Republic.
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MeSH Terms
Cardiopulmonary Bypass / methods*
Coronary Artery Bypass / methods*
Cytokines / metabolism
Gene Expression Regulation*
Interleukin-10 / metabolism
Methylprednisolone / pharmacology
Middle Aged
Neutrophil Activation
Neutrophils / cytology*,  metabolism*
Receptors, Interleukin-1 / biosynthesis
Surgical Procedures, Minimally Invasive
Reg. No./Substance:
0/Cytokines; 0/Receptors, Interleukin-1; 130068-27-8/Interleukin-10; 83-43-2/Methylprednisolone

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