Document Detail


The effect of controlled aprotinin administration through cardiotomy suction during cardiopulmonary bypass.
MedLine Citation:
PMID:  12395967     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardiotomy suction enhances inflammation and fibrinolysis during cardiopulmonary bypass (CPB). Aprotinin has been shown to reduce the generalized inflammatory insults associated with CPB. The purpose of this study was to evaluate the effect of Aprotinin administration through cardiotomy suction on the inflammatory and fibrinolytic responses during CPB. A pig model of CPB was utilized including 8 animals divided into control and treatment groups. In the treatment group, Aprotinin was infused into the cardiotomy suction (3000 KIU/min), while the same volume of saline was infused in the control group. D-dimer, platelet count, and IL-8 level were analyzed from systemic and cardiotomy suction. It was found that Aprotinin significantly suppressed the increase in D-dimer levels in the systemic (476.3 +/- 341.2 vs. 1218.8 +/- 281.3 ng/ml, p < 0.05) and the cardiotomy suction (565.0 +/- 192.5 vs. 1875.0 +/- 125.0 ng/ml, p < 0.05). Platelet count fell in both groups during CPB, although the reduction was greater in the control (13.1 +/- 5.1 vs. 37.9 +/- 13.8%, p < 0.05). In addition, IL-8 level in the suction solution was significantly lower in the Aprotinin group (56.5 +/- 18.0 vs. 136.3 +/- 14.8 pg/ml, p < 0.05). In conclusion, this study suggested that Aprotinin treatment of the cardiotomy solution might be an effective way of reducing fibrinolysis, platelet reduction, and inflammation associated with CPB.
Authors:
Jun-Li Liu; Alfred H Stammers; Hong Zheng; Nancy J Mills; Jeffery D Nichols; Scott A Kmiecik; Ryan J Kohtz; Craig M Petterson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of extra-corporeal technology     Volume:  34     ISSN:  0022-1058     ISO Abbreviation:  J Extra Corpor Technol     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-10-24     Completed Date:  2002-11-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0267637     Medline TA:  J Extra Corpor Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  203-8     Citation Subset:  T    
Affiliation:
Division of Clinical Perfusion Education, University of Nebraska Medical Center, School of Allied Health Professionals, Omaha 68198-5155, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Aprotinin / administration & dosage*,  therapeutic use
Cardiopulmonary Bypass*
Fibrin Fibrinogen Degradation Products / analysis
Interleukin-8 / analysis
Male
Platelet Count
Suction / adverse effects*
Swine
United States
Chemical
Reg. No./Substance:
0/Fibrin Fibrinogen Degradation Products; 0/Interleukin-8; 0/fibrin fragment D; 9087-70-1/Aprotinin

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