| The effect of continuous bleomycin infusion on the growth and cell kinetics of heterotransplanted squamous cell carcinoma of the head and neck. | |
| | |
MedLine Citation:
|
PMID: 2436565 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The schedule-dependent effect of bleomycin (BLM) on human squamous cell carcinoma (SCC) was investigated using a xenografted SCC line originating from the head and neck region. A total dose of 200 mg BLM/kg was administered according to one of three different schedules: one single i.p. injection; i.p. injection every four hours for seven days; and continuous s.c. administration for seven days via osmotic mini-pump. Both single dose treatment and iterated injections caused significant retardation of tumour growth, and continuous infusion had a more pronounced effect, almost completely retarding increase in tumour volume; these differences in effect in between the treatment schedules were not, however, statistically significant. The effect of continuous BLM infusion on cell cycle phase distribution and histopathological picture was also recorded. During the first three days of infusion, there was an accumulation of cells in Go/G1-phase paralleled by a depletion of cells in S-phase. This was followed by a normalisation during the rest of the infusion period, concomitant with a transient increase of the cells in G2-phase. Histopathologically, there were no changes during the first four days. A swelling of the cytoplasm cold then be seen; and after seven days, scattered groups of necrotic cells were observed which later formed necrotic foci. It is noteworthy that the major perturbances in cell cycle phase distribution preceded both retardation of tumour volume growth and histopathological changes. |
| | |
Authors:
|
P Wahlberg; J Wennerberg; P Alm; A Biörklund; C Tropé |
Related Documents
:
|
15565445 - Residual stress generation and necrosis formation in multi-cell tumour spheroids. 2908825 - Dynamic heterogeneity: experimental metastasis studies with rif-1 fibrosarcoma. 17845625 - Multiple cutaneous ganglioneuromas in a dog. 2444685 - Intermediate filaments cytokeratin and vimentin in ovarian sex cord-stromal tumours wit... 3690685 - Stress fiber reformation after atp depletion. 7730415 - Keratinocyte growth factor is a bifunctional regulator of hpv16 dna-immortalized cervic... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Anticancer research Volume: 7 ISSN: 0250-7005 ISO Abbreviation: Anticancer Res. Publication Date: 1987 Jan-Feb |
Date Detail:
|
Created Date: 1987-04-27 Completed Date: 1987-04-27 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: GREECE |
Other Details:
|
Languages: eng Pagination: 55-8 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Bleomycin / administration & dosage* Carcinoma, Squamous Cell / drug therapy* Cell Division / drug effects Drug Administration Schedule Female Head and Neck Neoplasms / drug therapy* Humans Infusion Pumps Injections, Intraperitoneal Mice Mice, Nude Neoplasm Transplantation Transplantation, Heterologous |
| Chemical | |
Reg. No./Substance:
|
11056-06-7/Bleomycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Extracellular proteins in breast tumor cytosol.
Next Document: Bladder instability in patients with prostatic hypertrophy. Urodynamic study