| The effect of compression on some physical properties of microcrystalline cellulose powders. | |
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MedLine Citation:
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PMID: 13179 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tablets have been prepared from previously characterized microcrystalline cellulose (Avicel) powders, using an instrumented single station tablet machine. The regenerated particle size was found to increase in compaction pressure. Compaction caused a slight initial decrease in B.E.T. surface area, followed by an increase mainly as a result of elastic recovery of the particles. The intra-particulate pore size distribution showed no change throughout the range of compaction pressures studied, demonstrating that the internal pores did not collapse. Measurement of the interparticulate porosity by mercury porosimetry, liquid penetration techniques and scanning electron microscopy showed a decrease in this parameter with increase in compaction pressure. The dissolution behaviour from the compacts showed in general a decreased rate with increase in compaction pressure, that from the cellulose grade PH 105 being slower than from the remaining grades. |
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Authors:
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D Sixsmith |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of pharmacy and pharmacology Volume: 29 ISSN: 0022-3573 ISO Abbreviation: J. Pharm. Pharmacol. Publication Date: 1977 Jan |
Date Detail:
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Created Date: 1977-03-31 Completed Date: 1977-03-31 Revised Date: 2000-12-18 |
Medline Journal Info:
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Nlm Unique ID: 0376363 Medline TA: J Pharm Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 33-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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1-Propanol Cellulose* Excipients Particle Size Powders Pressure Solubility Surface Properties Tablets* |
| Chemical | |
Reg. No./Substance:
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0/Excipients; 0/Powders; 0/Tablets; 71-23-8/1-Propanol; 9004-34-6/Cellulose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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