| The effect of compression force on surface structure, crushing strength, friability and disintegration time of erythromycin acistrate tablets. | |
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MedLine Citation:
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PMID: 9885307 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The surface roughness of erythromycin acistrate tablets was studied by non-contact laser profilometry. Seven roughness parameters and 3D fractal dimension were examined. The mechanical properties (including crushing strength, friability and disintegration time) were determined, and SEM data were taken from the tablets. According to the results, the crushing strength and the disintegration time of the tablets increased with increasing compression force. At higher compression forces the crushing strength reached a constant level. The friability of the tablets behaved quite unexpectedly and minimum friability was observed at a compression force of 14 kN. Except for fractal dimension, the roughness parameters behaved very much in the same way as the friability of the tablets. The SEM data supported the friability and surface roughness data of the tablets. |
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Authors:
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M Riippi; O Antikainen; T Niskanen; J Yliruusi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V Volume: 46 ISSN: 0939-6411 ISO Abbreviation: Eur J Pharm Biopharm Publication Date: 1998 Nov |
Date Detail:
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Created Date: 1999-04-01 Completed Date: 1999-04-01 Revised Date: 2000-12-18 |
Medline Journal Info:
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Nlm Unique ID: 9109778 Medline TA: Eur J Pharm Biopharm Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 339-45 Citation Subset: IM |
Copyright Information:
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Copyright 1998 Elsevier Science B.V. |
Affiliation:
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Pharmaceutical Technology Division, University of Helsinki, Helsinki, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chemistry, Pharmaceutical Compressive Strength Erythromycin / administration & dosage, analogs & derivatives*, chemistry Microscopy, Electron, Scanning Prodrugs / administration & dosage, chemistry* Surface Properties Tablets / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Prodrugs; 0/Tablets; 114-07-8/Erythromycin; 992-69-8/erythromycin 2'-acetate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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