| Effect of combining rosiglitazone with either metformin or insulin on β-cell mass and function in an animal model of Type 2 diabetes characterized by reduced β-cell mass at birth. | |
| | |
MedLine Citation:
|
PMID: 21040499 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Background: Interventions that preserve or increase β-cell mass may also prevent Type 2 diabetes. Rosiglitazone alone, as well as in combination with metformin, prevents diabetes in people with high, yet non-diabetic glucose levels. These effects may be mediated through changes in β-cell mass. In the present study, the effect of combining rosiglitazone with metformin and/or insulin on β-cell mass and glucose levels was examined in a rat model of Type 2 diabetes. Methods: Diabetes-prone pups were randomized to receive rosiglitazone alone or in combination with metformin and/or insulin starting at 4 weeks of age. β-Cell mass and glucose homeostasis were examined in adulthood. Results: Rosiglitazone treatment reduced insulin resistance and partially restored β-cell mass in animals with reduced β-cell mass at birth. The addition of metformin to rosiglitazone decreased insulin resistance and reduced weight gain, but had no additional effect on β-cell mass. Conversely, the addition of insulin had no additional effect on these outcomes. Although the combination of rosiglitazone and metformin did not affect β-cell mass at 26 weeks of age, it did result in reduced body weight and insulin resistance. Conclusion: The results of the present study suggest that the addition of metformin to rosiglitazone improves the metabolic profile through an effect on insulin resistance and not β-cell mass. |
| | |
Authors:
|
Alison C Holloway; Bart P Hettinga; Hertzel C Gerstein |
Related Documents
:
|
20880339 - In support of an early polypharmacy approach to the treatment of type 2 diabetes. 15975669 - Microalbuminuria as a marker of cardiovascular risk in patients with type 2 diabetes. 20307399 - Glucose supply and insulin demand dynamics of antidiabetic agents. 9737829 - A retrospective chart review of uncontrolled use of metformin as an add-on therapy in t... 8864639 - Clinical profile of the novel sulphonylurea glimepiride. 8112499 - Metformin--an update. 8432409 - Cd8+ t-cells are required for adoptive transfer of the bb rat diabetic syndrome. 20922819 - Evolution and predictors of morphological and functional arterial changes in the course... 3131049 - Anomeric specificity of d-glucose metabolism in human erythrocytes. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of diabetes Volume: 3 ISSN: 1753-0407 ISO Abbreviation: J Diabetes Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-02-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101504326 Medline TA: J Diabetes Country: Australia |
Other Details:
|
Languages: eng Pagination: 74-81 Citation Subset: IM |
Copyright Information:
|
© 2011 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd. |
Affiliation:
|
Reproductive Biology Division, Department of Obstetrics and Gynecology, McMaster University Department of Medicine, McMaster University, Hamilton, Ontario, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Tissue specificity on insulin action and resistance: past to recent mechanisms.
Next Document: Can dietary fructans lower serum glucose?