| The effect of combined calcium and cholecalciferol supplementation on bone mineral density in elderly women with moderate chronic kidney disease. | |
| | |
MedLine Citation:
|
PMID: 22551881 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIMS: To examine the effect of combined calcium and vitamin D3 supplementation on bone mineral density (BMD) inpatients with chronic kidney disease (CKD). METHODS: We performed a post-hoc analysis of the DECALYOS II, a 2-year randomized, double-blind, placebo-controlled study of 610 women randomized to: calcium-vitamin D3 fixed combination, calcium plus vitamin D3 separate combination, or placebo. Both active treatment groups received the same daily amount of calcium (1,200 mg) and vitamin D3 (800 IU). BMD of the distal radius was measured by single X-ray absorptiometry at baseline, 12 and 24 months. RESULTS: At baseline 47.2%, 36.4% and 16.4% of the study population had an eGFR ≥ 60, 45 -59, and < 45 ml/min/1.73 m2, respectively. Both active regimens vs. placebo markedly increased serum 25-hydroxyvitamin D levels from baseline in all eGFR groups (p 0.22 for all time points). CONCLUSION: Combined calcium and vitamin D3 supplementation was effective in reducing rate of BMD loss in women with moderate CKD. |
| | |
Authors:
|
Cortney Bosworth; Ian H de Boer; Giovanni Targher; Jessica Kendrick; Gerard Smits; Michel Chonchol |
Publication Detail:
|
Type: Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
|
Title: Clinical nephrology Volume: 77 ISSN: 0301-0430 ISO Abbreviation: Clin. Nephrol. Publication Date: 2012 May |
Date Detail:
|
Created Date: 2012-05-03 Completed Date: 2012-06-26 Revised Date: 2013-03-06 |
Medline Journal Info:
|
Nlm Unique ID: 0364441 Medline TA: Clin Nephrol Country: Germany |
Other Details:
|
Languages: eng Pagination: 358-65 Citation Subset: IM |
Affiliation:
|
University of Washington, Division of Nephrology and Kidney Research Institute, Seattle, WA, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Absorptiometry, Photon Age Factors Analysis of Variance Biological Markers / blood Bone Density / drug effects* Calcium / blood, therapeutic use* Chi-Square Distribution Cholecalciferol / blood, therapeutic use* Chronic Disease Dietary Supplements* Double-Blind Method Drug Combinations Drug Therapy, Combination Female Glomerular Filtration Rate Humans Institutionalization Kidney Diseases / blood, drug therapy*, physiopathology, radiography Placebos Radius / drug effects*, radiography Time Factors Treatment Outcome Vitamin D / analogs & derivatives, blood |
| Grant Support | |
ID/Acronym/Agency:
|
KL2 TR000421/TR/NCATS NIH HHS; UL1 TR000423/TR/NCATS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Drug Combinations; 0/Placebos; 1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D; 67-97-0/Cholecalciferol; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Normocalcemic hyperparathyroidism in patients with recurrent kidney stones: a disease entity or vita...
Next Document: Echocardiographic changes following hemodialysis initiation in patients with advanced chronic kidney...