Document Detail


The effect of colchicine on physical growth in children with familial mediterranean fever.
MedLine Citation:
PMID:  20016916     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Familial Mediterranean fever (FMF) is an autosomal recessive disease, characterized by recurrent, self-limited attacks of fever with serositis involving the peritoneum, pleura, and joints. There is very scarce information on physical growth of affected children. The aim of this study was to determine whether there is significant improvement in growth parameters in FMF patients after colchicine treatment. Patient files were retrospectively evaluated and patients that used colchicine for more than 1 year were included in the study. Demographic features, clinical findings before and after colchicine therapy, duration and dosage of therapy, weight, height, parentally adjusted height, and body mass index before and after colchicine therapy were noted and transformed into standard deviation scores (SDS). The study group consisted of 50 FMF (25 male and 25 female) patients. Median age at the time of diagnosis was 6.5 years. Median follow-up period was 3.6 (1-12.5) years. Mean height SDS increased from -0.19 +/- 1.01 to 0.13 +/- 0.99 (p = 0.026), and mean parentally adjusted height increased from -0.18 +/- 1.23 to 0.13 +/- 1.24 (p = 0.027), and both of them were found to be statistically significant. Mean body mass index SDS increased from -0.61 +/- 1.32 to -0.32 +/- 1.33, but this improvement was statistically insignificant (p = 0.18). In this study, we found that colchicine significantly improved height development in FMF patients.
Authors:
Z Birsin Ozçakar; Gülsüm Kadioğlu; Zeynep Siklar; Asli Kavaz; F Nur Aksanal; Merih Berberoğlu; Mesiha Ekim; Gönül Ocal; Fatoş Yalçinkaya
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Publication Detail:
Type:  Journal Article     Date:  2009-12-17
Journal Detail:
Title:  European journal of pediatrics     Volume:  169     ISSN:  1432-1076     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-05-26     Completed Date:  2010-09-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  825-8     Citation Subset:  IM    
Affiliation:
Division of Pediatric Nephrology, School of Medicine, Ankara University, Ankara, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Body Height / drug effects*
Body Mass Index
Child
Child, Preschool
Colchicine / pharmacology*
Familial Mediterranean Fever / drug therapy*,  physiopathology
Female
Gout Suppressants / pharmacology*
Growth Disorders / prevention & control*
Humans
Male
Retrospective Studies
Young Adult
Chemical
Reg. No./Substance:
0/Gout Suppressants; 64-86-8/Colchicine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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