| The effect of colchicine on physical growth in children with familial mediterranean fever. | |
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MedLine Citation:
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PMID: 20016916 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Familial Mediterranean fever (FMF) is an autosomal recessive disease, characterized by recurrent, self-limited attacks of fever with serositis involving the peritoneum, pleura, and joints. There is very scarce information on physical growth of affected children. The aim of this study was to determine whether there is significant improvement in growth parameters in FMF patients after colchicine treatment. Patient files were retrospectively evaluated and patients that used colchicine for more than 1 year were included in the study. Demographic features, clinical findings before and after colchicine therapy, duration and dosage of therapy, weight, height, parentally adjusted height, and body mass index before and after colchicine therapy were noted and transformed into standard deviation scores (SDS). The study group consisted of 50 FMF (25 male and 25 female) patients. Median age at the time of diagnosis was 6.5 years. Median follow-up period was 3.6 (1-12.5) years. Mean height SDS increased from -0.19 +/- 1.01 to 0.13 +/- 0.99 (p = 0.026), and mean parentally adjusted height increased from -0.18 +/- 1.23 to 0.13 +/- 1.24 (p = 0.027), and both of them were found to be statistically significant. Mean body mass index SDS increased from -0.61 +/- 1.32 to -0.32 +/- 1.33, but this improvement was statistically insignificant (p = 0.18). In this study, we found that colchicine significantly improved height development in FMF patients. |
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Authors:
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Z Birsin Ozçakar; Gülsüm Kadioğlu; Zeynep Siklar; Asli Kavaz; F Nur Aksanal; Merih Berberoğlu; Mesiha Ekim; Gönül Ocal; Fatoş Yalçinkaya |
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Publication Detail:
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Type: Journal Article Date: 2009-12-17 |
Journal Detail:
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Title: European journal of pediatrics Volume: 169 ISSN: 1432-1076 ISO Abbreviation: Eur. J. Pediatr. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-05-26 Completed Date: 2010-09-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603873 Medline TA: Eur J Pediatr Country: Germany |
Other Details:
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Languages: eng Pagination: 825-8 Citation Subset: IM |
Affiliation:
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Division of Pediatric Nephrology, School of Medicine, Ankara University, Ankara, Turkey. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Body Height / drug effects* Body Mass Index Child Child, Preschool Colchicine / pharmacology* Familial Mediterranean Fever / drug therapy*, physiopathology Female Gout Suppressants / pharmacology* Growth Disorders / prevention & control* Humans Male Retrospective Studies Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Gout Suppressants; 64-86-8/Colchicine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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