| The effect of cocaine, reserpine, and 6-hydroxydopamine on the response of the perfused central artery of the rabbit ear to sympathomimetic amines. | |
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MedLine Citation:
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PMID: 1139447 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The perfused central artery of the rabbit ear was less sensitive to extraluminal than to intraluminal noradrenaline, but the reverse was true for metaraminol, methoxamine, metanephrine, and isoproterenol. No difference was noted between the extraluminal and intraluminal potency of phenylephrine. Cocaine potentiated the effect of extraluminal and intraluminal noradrenaline, but decreased that of intraluminal phenylephrine. Irrespective of the route of administration, the constrictor potencies of the sympathomimetic amines were not affected by cocaine. Arteries of reserpine-treated rabbits were supersensitive to extraluminally and intraluminally applied noradrenaline and phenylephrine, but they were not supersensitive to metaraminol. 6-Hydroxydopamine effectively destroyed adrenergic nerve endings of the central ear artery and increased its responses to both extraluminal and intraluminal noradrenaline and phenylephrine. However, only the constrictor potencies of intraluminally applied metaraminol and methoxamine were enhanced by 6-hydroxydopamine. The apparent discrepancies between the results obtained by various procedures that eliminate or impair the nerve uptake process suggest that the difference in the constrictor potency of extraluminal and intraluminal sympathomimetic amines is probably unrelated to their uptake by nerves located in the adventitio-medial junction of the artery. |
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Authors:
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M S Yong; Chen P-C |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Canadian journal of physiology and pharmacology Volume: 53 ISSN: 0008-4212 ISO Abbreviation: Can. J. Physiol. Pharmacol. Publication Date: 1975 Feb |
Date Detail:
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Created Date: 1975-09-22 Completed Date: 1975-09-22 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372712 Medline TA: Can J Physiol Pharmacol Country: CANADA |
Other Details:
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Languages: eng Pagination: 38-46 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arteries / drug effects* Cocaine / pharmacology* Drug Synergism Ear / blood supply* Female Hydroxydopamines / pharmacology* Isoproterenol / pharmacology Male Metanephrine / pharmacology Metaraminol / pharmacology Methoxamine / pharmacology Nerve Endings / drug effects Norepinephrine / pharmacology Phenylephrine / pharmacology Rabbits Reserpine / pharmacology* Sympathomimetics / pharmacology* Vasomotor System / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Hydroxydopamines; 0/Sympathomimetics; 390-28-3/Methoxamine; 50-36-2/Cocaine; 50-55-5/Reserpine; 5001-33-2/Metanephrine; 51-41-2/Norepinephrine; 54-49-9/Metaraminol; 59-42-7/Phenylephrine; 7683-59-2/Isoproterenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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