| The effect of cocaine on myometrial contractile activity: basic mechanisms. | |
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MedLine Citation:
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PMID: 8857699 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several clinical studies have reported an association between cocaine use in pregnancy and preterm labor. The mechanism by which cocaine exerts this effect is unclear. Although cocaine stimulates isolated myometrial contractile activity, results using whole animal models are conflicting. Although cocaine inhibits uterine neuronal and extraneuronal uptake of catecholamines and increases circulating levels of catecholamines in experimental animals, it is unlikely that facilitation of the alpha-adrenergic pathway is the sole mechanism of cocaine's action. Further investigation of possible indirect mechanisms of action including altered prostaglandin production, inhibition of beta-adrenergic response, and direct effects on intracellular calcium mobilization may lead to enhanced understanding of the clinical ramifications of cocaine use during pregnancy. |
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Authors:
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M Monga |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Seminars in perinatology Volume: 20 ISSN: 0146-0005 ISO Abbreviation: Semin. Perinatol. Publication Date: 1996 Apr |
Date Detail:
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Created Date: 1997-01-02 Completed Date: 1997-01-02 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7801132 Medline TA: Semin Perinatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 140-6 Citation Subset: IM |
Affiliation:
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Department Obstetrics, Gynecology, and Reproductive Sciences, University of Texas Health Science Center-Houston 77030, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Catecholamines / physiology Cocaine* Female Obstetric Labor, Premature / chemically induced* Pregnancy Signal Transduction / drug effects Substance-Related Disorders* Uterine Contraction / drug effects* Vascular Resistance / drug effects Vasoconstriction / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines; 50-36-2/Cocaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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