Document Detail

The effect of cocaine and amphetamines on vital signs in trauma patients.
MedLine Citation:
PMID:  7782627     Owner:  NLM     Status:  MEDLINE    
The object of this study was to determine if the presence of sympathomimetics (cocaine, benzoylecgonine, or amphetamine), detected by routine urine toxicology screen, affect the initial presenting pulse, blood pressure, respiratory rate, or level of consciousness in trauma patients. A retrospective chart review was performed on 1,679 patients enrolled in an urban level 1 trauma registry between October 1987, and July 1992, for whom complete toxicology data were available. There were no clinically significant differences in the vital signs of patients with positive toxicology screens and those with negative screens. There was a statistically significant increase in prehospital respiratory rate among patients with benzoylecgonine or amphetamines on admission toxicology screens when potential confounding factors were controlled. However, these effects disappeared upon arrival at the hospital. The detection of sympathomimetics by toxicology screening had no effect on pulse and systolic blood pressure when age, sex, mechanism, type, and severity of injury, prehospital IV fluid volume, and alcohol intoxication were controlled.
C F Richards; R F Clark; T Holbrook; D B Hoyt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of emergency medicine     Volume:  13     ISSN:  0736-4679     ISO Abbreviation:  J Emerg Med     Publication Date:    1995 Jan-Feb
Date Detail:
Created Date:  1995-07-17     Completed Date:  1995-07-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8412174     Medline TA:  J Emerg Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  59-63     Citation Subset:  IM    
Department of Emergency Medicine, University of California, San Diego 92103-8676, USA.
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MeSH Terms
Amphetamines / pharmacology*,  urine
Blood Pressure / drug effects
Cocaine / analogs & derivatives,  pharmacology*,  urine
Emergency Medical Services
Pulse / drug effects
Respiration / drug effects
Retrospective Studies
Substance Abuse Detection*
Unconsciousness / physiopathology
Wounds and Injuries / physiopathology*
Reg. No./Substance:
0/Amphetamines; 50-36-2/Cocaine; 519-09-5/benzoylecgonine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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