Document Detail

The effect of clonidine on sevoflurane requirements for anaesthesia and hypnosis.
MedLine Citation:
PMID:  9135194     Owner:  NLM     Status:  MEDLINE    
We evaluated the effects of clonidine given orally on sevoflurane requirements for anaesthesia and hypnosis. Patients received either clonidine (5 by mouth (n = 21) 90 min before surgery or no premedication (n = 21) by random allocation. MAC was calculated using repeated tetanic nerve stimulation with end-tidal sevoflurane concentration increased or decreased by 0.3 vol.% depending on the previous response. MAC awake was calculated according to the response to verbal command. The mean (SD) MAC in the clonidine-treated patients was 1.53 (0.20)% compared with 1.83 (0.15)% in the control group (p < 0.001). Similarly, MAC awake was reduced in the clonidine group (0.50 (0.08)% compared with 0.60 (0.07)% in the control group) (p < 0.001). We conclude that clonidine 5 orally administered pre-operatively reduces sevoflurane requirements for anaesthesia and hypnosis.
T Katoh; K Ikeda
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anaesthesia     Volume:  52     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-05-19     Completed Date:  1997-05-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  377-81     Citation Subset:  AIM; IM    
Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, Japan.
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MeSH Terms
Anesthetics, Inhalation*
Clonidine / pharmacology*
Dose-Response Relationship, Drug
Drug Synergism
Electric Stimulation
Hypnosis, Anesthetic*
Methyl Ethers*
Middle Aged
Movement / drug effects
Sympatholytics / pharmacology*
Reg. No./Substance:
0/Anesthetics, Inhalation; 0/Ethers; 0/Methyl Ethers; 0/Sympatholytics; 28523-86-6/sevoflurane; 4205-90-7/Clonidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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