| The effect of clonidine on sevoflurane requirements for anaesthesia and hypnosis. | |
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MedLine Citation:
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PMID: 9135194 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We evaluated the effects of clonidine given orally on sevoflurane requirements for anaesthesia and hypnosis. Patients received either clonidine (5 micrograms.kg-1) by mouth (n = 21) 90 min before surgery or no premedication (n = 21) by random allocation. MAC was calculated using repeated tetanic nerve stimulation with end-tidal sevoflurane concentration increased or decreased by 0.3 vol.% depending on the previous response. MAC awake was calculated according to the response to verbal command. The mean (SD) MAC in the clonidine-treated patients was 1.53 (0.20)% compared with 1.83 (0.15)% in the control group (p < 0.001). Similarly, MAC awake was reduced in the clonidine group (0.50 (0.08)% compared with 0.60 (0.07)% in the control group) (p < 0.001). We conclude that clonidine 5 micrograms.kg-1 orally administered pre-operatively reduces sevoflurane requirements for anaesthesia and hypnosis. |
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Authors:
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T Katoh; K Ikeda |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Anaesthesia Volume: 52 ISSN: 0003-2409 ISO Abbreviation: Anaesthesia Publication Date: 1997 Apr |
Date Detail:
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Created Date: 1997-05-19 Completed Date: 1997-05-19 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370524 Medline TA: Anaesthesia Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 377-81 Citation Subset: AIM; IM |
Affiliation:
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Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anesthetics, Inhalation* Clonidine / pharmacology* Dose-Response Relationship, Drug Drug Synergism Electric Stimulation Ethers* Female Humans Hypnosis, Anesthetic* Male Methyl Ethers* Middle Aged Movement / drug effects Premedication Sympatholytics / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 0/Ethers; 0/Methyl Ethers; 0/Sympatholytics; 28523-86-6/sevoflurane; 4205-90-7/Clonidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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