Document Detail


The effect of a clinically effective and non-effective dose of lorazepam on 7.5% CO(2) -induced anxiety.
MedLine Citation:
PMID:  23027657     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Symptoms of anxiety induced by 7.5% CO(2) inhalation can be attenuated by acute administration of GABA(A) receptor anxiolytics such as lorazepam and alprazolam. This study investigated if these effects are dose-related, by comparing a 0.5 mg dose (considered non-clinically effective) and a 2 mg dose of lorazepam (clinically effective) on 7.5% CO(2) inhalation. Eighteen healthy males (mean age 20.6 years, SD 1.29), judged physically and mentally fit, attended three visits, each one week apart, to take each treatment in a randomised double-blind crossover design. Drugs were given 60 min prior to 20 min air inhalation, followed by 20 min 7.5% CO(2) inhalation. The order of gas presentation was single blind. Subjective ratings using visual analogue scales (VAS) and questionnaires were recorded before and after each inhalation. Blood pressure (BP), heart rate (HR), respiration rate (RR) and expired CO(2) were recorded during each inhalation. Inhalation of 7.5% CO(2) significantly raised BP, HR, RR and expired CO(2) . Ratings of feeling like leaving the room were significantly lower on 2 mg compared with 0.5 mg and placebo, and dose-dependent trends were seen in scores for VAS fearful, anxious, stressed, tense, and worried. Results may be indicative of dose-dependent effects of lorazepam in a CO(2) model of anxiety. Copyright © 2012 John Wiley & Sons, Ltd.
Authors:
Alison Diaper; Andreas Papadopoulos; Ann S Rich; Gerry R Dawson; Colin T Dourish; David J Nutt; Jayne E Bailey
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-2
Journal Detail:
Title:  Human psychopharmacology     Volume:  -     ISSN:  1099-1077     ISO Abbreviation:  Hum Psychopharmacol     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8702539     Medline TA:  Hum Psychopharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 John Wiley & Sons, Ltd.
Affiliation:
Psychopharmacology Unit, University of Bristol, Academic Unit of Psychiatry, Bristol, UK. alison_diaper@hotmail.com.
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