Document Detail

The effect of citric acid and its sodium salts in test meals on the gastric outputs of acid and of chloride.
MedLine Citation:
PMID:  4702420     Owner:  NLM     Status:  MEDLINE    
Five subjects were given 750 ml. test meals lasting 10-20 min, containing 0-300 mN citric acid, monosodium dihydrogen citrate, disodium monohydrogen citrate or trisodium citrate.1. Increase in concentration of sodium citrate in the range 0-125 mN gave increasing outputs of acid and chloride.2. The more acid the meal for any given citrate ion concentration, the less the output of acid and chloride.3. The greater the concentration of an acid citrate salt, the less the output of acid.4. There was evidence of loss of acid from the stomach by diffusion with the more acid meals.
J N Hunt; M T Knox
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of physiology     Volume:  230     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  1973 Apr 
Date Detail:
Created Date:  1973-07-05     Completed Date:  1973-07-05     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  171-84     Citation Subset:  IM    
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MeSH Terms
Chlorides / secretion*
Citrates / administration & dosage,  pharmacology*
Gastric Juice / secretion*
Gastric Mucosa / drug effects,  metabolism,  secretion
Hydrogen-Ion Concentration
Secretory Rate / drug effects
Sensory Receptor Cells
Stomach / innervation
Reg. No./Substance:
0/Chlorides; 0/Citrates; 7440-23-5/Sodium

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