| The effect of cisapride and metoclopramide on human digestive and interdigestive antroduodenal motility. | |
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MedLine Citation:
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PMID: 7886398 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: To date, there is little information available about the effect of cisapride and metoclopramide on gastroduodenal pressure waves and their space/time orientation. METHODS: Antroduodenal pressures (two antral, three duodenal recording sites) were measured in nine healthy volunteers. Cisapride (10 mg), metoclopramide (10 mg), and placebo were administered intravenously on different days in a randomized manner. RESULTS: During the interdigestive state cisapride increased the motility index significantly in the antrum (p < 0.05) and duodenum (p < 0.005), metoclopramide only in the duodenum (p < 0.01). Antroduodenal coordination was significantly (p < 0.01) improved by cisapride but not by metoclopramide. There is evidence of antroduodenal coordination even during the interdigestive state. After a liquid test meal an increase in the antroduodenal motility index (p < 0.05), in the rate of prograde antroduodenal peristalsis (p < 0.01), and in antroduodenal coordination (p < 0.01) was caused by cisapride but not metoclopramide. Both prokinetics decreased (p < 0.01) retrograde antroduodenal peristalsis. CONCLUSION: Cisapride significantly improves antroduodenal coordination and antroduodenal motility; metoclopramide seems to be less effective. |
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Authors:
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G Lux; M Katschinski; S Ludwig; P Lederer; A Ellermann; W Domschke |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Scandinavian journal of gastroenterology Volume: 29 ISSN: 0036-5521 ISO Abbreviation: Scand. J. Gastroenterol. Publication Date: 1994 Dec |
Date Detail:
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Created Date: 1995-04-13 Completed Date: 1995-04-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0060105 Medline TA: Scand J Gastroenterol Country: NORWAY |
Other Details:
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Languages: eng Pagination: 1105-10 Citation Subset: IM |
Affiliation:
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Dept. of Medicine, Clinic A, University of Erlangen-Nuremberg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cisapride Digestion / drug effects, physiology Double-Blind Method Duodenum / drug effects, physiology Female Gastrointestinal Motility / drug effects*, physiology Humans Infusions, Intravenous Male Manometry Metoclopramide / administration & dosage, pharmacology* Piperidines / administration & dosage, pharmacology* Pyloric Antrum / drug effects, physiology Serotonin Antagonists / administration & dosage, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Piperidines; 0/Serotonin Antagonists; 364-62-5/Metoclopramide; 81098-60-4/Cisapride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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