Document Detail


The effect of cisapride on duodenal acid exposure in the proximal duodenum in healthy subjects.
MedLine Citation:
PMID:  10233185     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To investigate the effect of the prokinetic drug, cisapride, on fasting and postprandial acid exposure in the proximal duodenum. METHODS: Using a double-blind, placebo-controlled crossover study design, 12 healthy male volunteers were studied. After 1 week of dosing (cisapride 20 mg b.d. orally or placebo), fasting and postprandial antroduodenal pH-and pressure-recordings were made. Using a small-caliber (4 mm) catheter, containing one antral and two duodenal pH electrodes, and two antral and three duodenal pressure recording sites. Transmucosal potential difference was measured to ensure proper catheter position. Infusions of 0.1 N HCl were given in the duodenal bulb. RESULTS: Endogenous acidification of the duodenal bulb occurred more frequently during phase II and postprandially, compared to phase I (P<0.001). During phase I, alkalinization of the antrum was observed. Cisapride significantly increased the postprandial number of duodenal acidic periods (P<0.02), but shortened their duration (P<0.04). The duodenal motor response elicited by exogenous acid was lower during phase I (P<0.05). CONCLUSIONS: Antral and proximal duodenal acidity vary with the phases of the interdigestive motor complex. Cisapride shortens the individual periods of duodenal acidification.
Authors:
M A Verhagen; J M Roelofs; M A Edelbroek; A J Smout; L M Akkermans
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Alimentary pharmacology & therapeutics     Volume:  13     ISSN:  0269-2813     ISO Abbreviation:  Aliment. Pharmacol. Ther.     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-06-10     Completed Date:  1999-06-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8707234     Medline TA:  Aliment Pharmacol Ther     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  621-30     Citation Subset:  IM    
Affiliation:
Gastrointestinal Motility Unit, University Hospital, Utrecht, The Netherlands. marcanne@knmg.nl
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MeSH Terms
Descriptor/Qualifier:
Adult
Anti-Ulcer Agents / pharmacology*
Cisapride / pharmacology*
Cross-Over Studies
Double-Blind Method
Duodenum / drug effects*,  metabolism
Gastrointestinal Motility
Humans
Hydrochloric Acid / pharmacology*
Hydrogen-Ion Concentration
Male
Postprandial Period
Chemical
Reg. No./Substance:
0/Anti-Ulcer Agents; 7647-01-0/Hydrochloric Acid; 81098-60-4/Cisapride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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