| The effect of cibenzoline on myocardial damages in dogs. | |
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MedLine Citation:
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PMID: 2757658 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The antiarrhythmic and cardioprotective effects of cibenzoline (4,5-dihydro-2-(2,2-diphenylcyclopropyl)-1H-imidazole) were investigated. Nineteen adult mongrel dogs were divided into 2 groups; in the control group, physiological saline (25 ml) was administered, and 20 min after, the left anterior descending coronary artery (LAD) was occluded for 2 h; in the cibenzoline group, cibenzoline (2 mg/kg), was administered 10 min before 2 h LAD occlusion. Blood pressure and appearance of arrhythmias were monitored throughout the experiment. Two h after occlusion, mitochondria were prepared from both ischemic and non-ischemic areas in each group, and their functions were measured polarographically. Fractionation of myocardial tissue from both ischemic and non-ischemic areas was performed, and activities of lysosomal enzymes (N-acetyl-beta-glucosaminidase and beta-glucuronidase) were measured in each fraction. Administration of cibenzoline significantly reduced the appearance of ventricular arrhythmias in association with ischemia. Cibenzoline did not change significantly blood pressure and heart rate. In the control group, mitochondrial dysfunction and leakage of lysosomal enzymes induced by 2 h occlusion were observed. Administration of cibenzoline maintained significantly mitochondrial function and prevented significantly leakage of lysosomal enzymes. These results indicated that cibenzoline has a cardioprotective as well as an antiarrhythmic effect on ischemic myocardium. |
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Authors:
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K Taki; S Sugiyama; N Hieda; Y Hanaki; T Sano; Y Shimada; T Ozawa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Arzneimittel-Forschung Volume: 39 ISSN: 0004-4172 ISO Abbreviation: Arzneimittelforschung Publication Date: 1989 Mar |
Date Detail:
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Created Date: 1989-09-01 Completed Date: 1989-09-01 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372660 Medline TA: Arzneimittelforschung Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 325-8 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, Faculty of Medicine, University of Nagoya, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Arrhythmia Agents / therapeutic use* Blood Pressure / drug effects Cardiomyopathies / drug therapy* Dogs Female Glucuronidase / metabolism Heart Rate / drug effects Imidazoles / therapeutic use* Lysosomes / enzymology Male Mitochondria, Heart / enzymology Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 0/Imidazoles; 53267-01-9/cifenline; EC 3.2.1.31/Glucuronidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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