Document Detail

The effect of chronic pulmonary hypertension on left ventricular size, function, and interventricular septal motion.
MedLine Citation:
PMID:  3578005     Owner:  NLM     Status:  MEDLINE    
The effect of right ventricular pressure overload secondary to chronic pulmonary arterial hypertension on left ventricular size and function and on interventricular septal motion was studied in 13 patients in whom coronary artery disease, hypertension, and hypoxemia were excluded. Regional and global left ventricular function were assessed by computer-assisted analysis of two-dimensional directed M-mode echocardiograms obtained within 24 hours of a hemodynamic study. Septal position and motion were further analyzed by delineating seven points along the right and left sides of the septum during a single cardiac cycle. All echocardiographic data were compared to those of 10 normal subjects. Mean values for right ventricular systolic, mean pulmonary artery and pulmonary capillary wedge pressures were: 71 +/- 26 mm Hg, 46 +/- 16 mm Hg, and 7 +/- 1 mm Hg, respectively. Septal motion was interpreted from the M-mode echocardiograms as normal in seven patients (group I) and abnormal in the remaining six patients (group II). The only hemodynamic parameter which distinguished these two patterns was delta P, the transseptal systolic pressure gradient across the interventricular septum, which was significantly different (p less than 0.02) in group I (delta P = 65 +/- 16 mm Hg) from that of group II (delta P = 21 +/- 24 mm Hg). As a result of abnormal septal position, the septal-free wall dimensions of the left ventricle were reduced, but there was no evidence of depressed left ventricular performance in these patients. We conclude that resting left ventricular function is well preserved in patients with pulmonary hypertension, despite significant alterations in septal position and left ventricular size.(ABSTRACT TRUNCATED AT 250 WORDS)
M Jessup; M S Sutton; K T Weber; J S Janicki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  113     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-06-02     Completed Date:  1987-06-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1114-22     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure
Heart / physiopathology*
Heart Septum / pathology,  physiopathology*
Heart Ventricles / pathology,  physiopathology
Hypertension, Pulmonary / pathology,  physiopathology*
Middle Aged
Myocardium / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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