Document Detail

The effect of chronic lithium treatment on the sialic acid content in rat brain synaptosomes.
MedLine Citation:
PMID:  7223439     Owner:  NLM     Status:  MEDLINE    
Rats were fed a lithium-containing diet for five weeks (40 mmol LiCl/kg fodder). Plasma lithium concentration was 0.44 mmol Li+/l plasma. The synaptosomes were isolated an incubated with 3H-glucosamine for 60 min. The glycopeptides and the gangliosides were extracted and the sialic acid content and the 3H-sialic acid content were measured. The lithium treatment produced an increase in the synaptosomal glycopeptide content. The sialic acid content was simultaneously increased in glycopeptides as well as gangliosides. The specific activity of sialic acid was reduced to 75% of the control value in the sialoglycopeptide fraction.
S Edelfors
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta pharmacologica et toxicologica     Volume:  48     ISSN:  0001-6683     ISO Abbreviation:  Acta Pharmacol Toxicol (Copenh)     Publication Date:  1981 Jan 
Date Detail:
Created Date:  1981-06-23     Completed Date:  1981-06-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370572     Medline TA:  Acta Pharmacol Toxicol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  61-4     Citation Subset:  IM    
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MeSH Terms
Brain / metabolism*
Gangliosides / metabolism
Lithium / blood,  pharmacology*
Sialic Acids / metabolism*
Sialoglycoproteins / metabolism
Synaptosomes / metabolism*
Time Factors
Reg. No./Substance:
0/Gangliosides; 0/Sialic Acids; 0/Sialoglycoproteins; 7439-93-2/Lithium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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