Document Detail

The effect of chronic fatty acid treatment on lipolysis in 3T3-L1 adipocytes.
MedLine Citation:
PMID:  1697464     Owner:  NLM     Status:  MEDLINE    
Various saturated and unsaturated fatty acids were included in the culture medium to test their effects on lipolysis in 3T3-L1 adipocytes. Following prolonged incubation, only oleate was found to exert enhancing effect on basal and isoproterenol-stimulated lipolysis. The effect of oleate was concentration-dependent and was accompanied with increased intracellular cAMP content. Furthermore, the lipolytic response induced by isobutyl-methylxanthine, forskolin or dibutyryl cAMP was also increased in adipocytes treated with oleate. Thus, it appears that in addition to an increased cAMP accumulation, a step distal to cAMP production in the cells may be involved in inducing enhanced lipolysis in 3T3-L1 adipocytes by prolonged exposure to oleate.
J C Fong
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  171     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-10-04     Completed Date:  1990-10-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  46-52     Citation Subset:  IM    
Institute of Biochemistry, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China.
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MeSH Terms
1-Methyl-3-isobutylxanthine / pharmacology
Adipose Tissue / metabolism*
Bucladesine / pharmacology
Cell Line
Dose-Response Relationship, Drug
Fatty Acids / metabolism*
Forskolin / pharmacology
Lipid Mobilization* / drug effects
Oleic Acid
Oleic Acids / pharmacology*
Reg. No./Substance:
0/Fatty Acids; 0/Oleic Acids; 112-80-1/Oleic Acid; 28822-58-4/1-Methyl-3-isobutylxanthine; 362-74-3/Bucladesine; 66428-89-5/Forskolin

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