| The effect of chronic fatty acid treatment on lipolysis in 3T3-L1 adipocytes. | |
MedLine Citation:
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PMID: 1697464 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Various saturated and unsaturated fatty acids were included in the culture medium to test their effects on lipolysis in 3T3-L1 adipocytes. Following prolonged incubation, only oleate was found to exert enhancing effect on basal and isoproterenol-stimulated lipolysis. The effect of oleate was concentration-dependent and was accompanied with increased intracellular cAMP content. Furthermore, the lipolytic response induced by isobutyl-methylxanthine, forskolin or dibutyryl cAMP was also increased in adipocytes treated with oleate. Thus, it appears that in addition to an increased cAMP accumulation, a step distal to cAMP production in the cells may be involved in inducing enhanced lipolysis in 3T3-L1 adipocytes by prolonged exposure to oleate. |
Authors:
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J C Fong |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 171 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1990 Aug |
Date Detail:
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Created Date: 1990-10-04 Completed Date: 1990-10-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 46-52 Citation Subset: IM |
Affiliation:
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Institute of Biochemistry, National Yang-Ming Medical College, Taipei, Taiwan, Republic of China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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1-Methyl-3-isobutylxanthine
/
pharmacology Adipose Tissue / metabolism* Animals Bucladesine / pharmacology Cell Line Dose-Response Relationship, Drug Fatty Acids / metabolism* Forskolin / pharmacology Lipid Mobilization* / drug effects Mice Oleic Acid Oleic Acids / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Oleic Acids; 112-80-1/Oleic Acid; 28822-58-4/1-Methyl-3-isobutylxanthine; 362-74-3/Bucladesine; 66428-89-5/Forskolin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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