Document Detail

The effect of chronic alcohol intoxication and smoking on the activity of oral peroxidase.
MedLine Citation:
PMID:  23042278     Owner:  NLM     Status:  In-Data-Review    
Peroxidase is the most important antioxidant enzyme in saliva. Through peroxidation of thiocyanate inthe presence of H2O2, peroxidase catalyses the formation of bacteriocidic compounds such as hypothiocyanate.The purpose of this study was to evaluate the effect of chronic alcohol intoxication and smoking on the activityof oral peroxidase (OPO). A total of 37 volunteers participated in the study. This cohort consisted of 17 malealcohol-dependent smoking patients after chronic alcohol intoxication (AS group, alcohol + smoking) (meanage: 42 years; range: 26-55) (100-700 g/day of alcohol; 10-20 cigarettes/day) and 20 control male social drinkers(CNS group, control non-smokers) with no history of alcohol abuse or smoking (mean age: 42 years; range:30-53). Salivary peroxidase activity was measured by the colorimetric method. The differences between groupswere evaluated using the Mann-Whitney U test. There was significantly higher activity of OPO (p = 0.00001)and significantly lower salivary flow (SF) (p = 0.007) in alcohol-dependent smokers after chronic alcohol intoxicationcompared to the control group. OPO activity significantly correlated with the number of days of alcoholintoxication, but not with smoking. Gingival index (GI) was significantly higher in smoking alcohol-dependentpersons than in the control group, and correlated with OPO activity. The sensitivity of the OPO test was 70% insmoking alcoholics, while specificity was 95%. The increased activity of OPO suggests chronic oxidative stress ismore likely due to ethanol action than to smoking. Smoking alcohol-dependent persons have a worse periodontalstatus than controls. OPO activity as a marker of chronic alcohol abuse may help in the diagnosis of alcoholism.
Napoleon Waszkiewicz; Anna Zalewska; Sławomir Dariusz Szajda; Agata Szulc; Alina Kępka; Alina Minarowska; Marzena Wojewódzka-Żelezniakowicz; Beata Konarzewska; Sylwia Chojnowska; Zbigniew Bronisław Supronowicz; Jerzy Robert Ladny; Krzysztof Zwierz
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Publication Detail:
Type:  Journal Article     Date:  2012-10-08
Journal Detail:
Title:  Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society     Volume:  50     ISSN:  1897-5631     ISO Abbreviation:  Folia Histochem. Cytobiol.     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8502651     Medline TA:  Folia Histochem Cytobiol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  450-5     Citation Subset:  IM    
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