Document Detail


The effect of chronic L-carnitine treatment on blood pressure and plasma lipids in spontaneously hypertensive rats.
MedLine Citation:
PMID:  9548391     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of chronic L-carnitine treatment on blood pressure and plasma lipids was studied in spontaneously hypertensive rats (SHR). L-Carnitine treatment for 6 weeks lowered significantly both the systolic and mean arterial pressure of SHR but its influence on diastolic and pulse pressure was only modest. L-Carnitine did not influence the relative heart and kidney weight of SHR. However, L-carnitine completely abolished the age-dependent rise of plasma total cholesterol, triglycerides and uric acid seen in untreated SHR. On the other hand, L-carnitine treatment had no significant effects on blood pressure, relative organ weight and plasma lipids in normotensive Wistar-Kyoto rats. Our results suggest that L-carnitine might prevent some cardiovascular alterations by its influence on lipid metabolism.
Authors:
H Rauchová; Z Dobesová; Z Drahota; J Zicha; J Kunes
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  342     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-06-08     Completed Date:  1998-06-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  235-9     Citation Subset:  IM    
Affiliation:
Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska, Prague.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects*
Body Weight / drug effects
Carnitine / blood,  pharmacology*
Heart Rate / drug effects
Hypertension / blood,  genetics,  physiopathology*
Lipids / blood*
Male
Organ Size / drug effects
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Uric Acid / blood
Chemical
Reg. No./Substance:
0/Lipids; 541-15-1/Carnitine; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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