Document Detail

The effect of cholestasis on rewarding and exploratory behaviors induced by opioidergic and dopaminergic agents in mice.
MedLine Citation:
PMID:  23020537     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Several investigations have indicated that cholestasis decreases opioid receptor expression in the brain following increased opioidergic neurotransmission. The opioidergic system plays an important role in regulation of reward circuits that may be produced via dopamine-dependent mechanisms. It has been suggested that the dopaminergic system of the nucleus accumbens is necessary in conditioned place preference (CPP). The aim of this study is, therefore, to test if cholestasis can alter the reward system and the involvement of opioidergic and dopaminergic systems in this phenomenon. 
METHODS: We used CPP and hole-board paradigms to measure the reward effect and exploratory behaviors, respectively, in mice. Cholestasis was induced by ligation of the main bile duct, using two ligatures and transecting the duct between them (BDL mice). 
RESULTS: The data showed that morphine (1 and 2 mg/kg), sulpiride (80 mg/kg) and SKF38393 (20 mg/kg) produced CPP, while naloxone (1 mg/kg) and SCH23390 (1mg/kg) produced conditioned place aversion (CPA), whereas quinpirole had no effect in sham-operated mice. However, morphine (2 mg/kg, i.p.), sulpiride (40 mg/kg) and? SKF38393 (10 mg/kg) induced CPP in BDL mice compared to sham-operated mice. Naloxone- or SCH23390-induced CPA was reduced in BDL mice compared with the respective sham-operated mice. Quinpirole tended to induce aversion in BDL mice which was, however, not significant. In addition, quinpirole 1 mg/kg) and SCH23390 (1 mg/kg) increased head-dip exploratory behavior, whereas naloxone (2 mg/kg) caused a decrease in head-dip exploratory behavior in sham-operated mice. Morphine (2 mg/kg), SCH23390 (1 mg/kg) and quinpirole (0.25 and 0.5 mg/kg) induced anxiogenic-like behavior in BDL mice. 
CONCLUSION: It can be concluded that cholestasis differentially alters the reward effects of opioidergic and dopaminergic agents.
Mohaddeseh Ebrahimi-ghiri; Mohammad Nasehi; Parvin Rostami; Homa Mohseni-Kouchesfehani; Mohammad Reza Zarrindast
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of Iranian medicine     Volume:  15     ISSN:  1735-3947     ISO Abbreviation:  Arch Iran Med     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-01     Completed Date:  2013-02-04     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  100889644     Medline TA:  Arch Iran Med     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  617-24     Citation Subset:  IM    
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MeSH Terms
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / pharmacology
Analgesics, Opioid / pharmacology
Analysis of Variance
Behavior, Animal / drug effects*
Benzazepines / pharmacology
Cholestasis / physiopathology*
Dopamine Agents / pharmacology
Exploratory Behavior / drug effects*
Morphine / pharmacology
Naloxone / pharmacology
Narcotic Antagonists / pharmacology
Quinpirole / pharmacology
Sulpiride / pharmacology
Reg. No./Substance:
0/Analgesics, Opioid; 0/Benzazepines; 0/Dopamine Agents; 0/Narcotic Antagonists; 0/SCH 23390; 20OP60125T/Quinpirole; 36B82AMQ7N/Naloxone; 67287-49-4/2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 76I7G6D29C/Morphine; 7MNE9M8287/Sulpiride

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