| The effect of cholecalciferol and calcitriol on biochemical bone markers in HIV-1 infected males: results of a clinical trial. | |
| | |
MedLine Citation:
|
PMID: 23199009 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Introduction: HIV-1 infected patients have an increased risk of osteoporosis and fractures. The main objective of this study was to evaluate the bone metabolism in HIV-1 infected patients exposed to calcitriol and cholecalciferol. We also investigated the relationship between T cells and bone markers. Methods: We conducted a placebo controlled randomized study running for 16 weeks including 61 HIV-1 infected males, of whom 51 completed the protocol. Nine-teen participants were randomized to daily treatment with A) 0.5-1.0 μg calcitriol and 1200 IU (30 μg) cholecalciferol, 17 participants to B) 1200 IU cholecalciferol, and 15 participants to C) placebo. At baseline and after 16 weeks, we determined collagen type 1 trimeric cross-linked peptide (CTx), procollagen type 1 N-terminal peptide (P1NP), parathyroid hormone (PTH), ionized calcium, 25-hydroxy vitamin D (25OHD), and 1,25-dihydroxy vitamin D (1,25(OH)2D). We determined naïve CD4+ and CD8+, activated CD4+ and CD8+, and regulatory CD4+CD25+CD127(low) T lymphocytes. Results: Baseline levels of P1NP and CTx correlated (coefficient 0.5, p<0.001) with each other but not with PTH, 25OHD, nor 1,25(OH)2D. In patients receiving calcitriol and cholecalciferol, mean levels of P1NP (p<0.001) and CTx (p=0.002) declined significantly compared to our placebo group. Based on changes in P1NP and CTx, we estimated that net bone formation occurred more frequently in group A compared to group B and C. PTH correlated inversely with naïve CD4+ and CD8+ cells. Otherwise, no relationships between bone markers and T lymphocytes were demonstrated. Conclusion: Supplementation with calcitriol and cholecalciferol induced biochemical indications of bone formation in HIV-1 patients. |
| | |
Authors:
|
Ulrich Christian Bang; Lilian Kolte; Mette Hitz; Louise Lind Schierbeck; Susanne Dam Nielsen; Thomas Benfield; Jens-Erik Beck Jensen |
Related Documents
:
|
23291609 - Alendronate protects against articular cartilage erosion by inhibiting subchondral bone... 23528629 - Total knee arthroplasty using anatomic alignment can produce mid-flexion laxity. 23428769 - Effects of demineralized bone matrix on tendon-bone healing: an in vivo, experimental s... 23064899 - Technetium-99 conjugated with methylene diphosphonate ameliorates ovariectomy-induced o... 23088529 - Use of a collagen membrane loaded with collagen-targeting recombinant human bone morpho... 7208679 - A simple technique for reduction of the earlobe. 1363389 - Experimental structural scoliosis in rabbits. 7735639 - An intramedullary aligned bone cutting jig for elbow replacement. 22070169 - Polycaprolactone scaffolds fabricated with an advanced electrohydrodynamic direct-print... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-12-2 |
Journal Detail:
|
Title: AIDS research and human retroviruses Volume: - ISSN: 1931-8405 ISO Abbreviation: AIDS Res. Hum. Retroviruses Publication Date: 2012 Dec |
Date Detail:
|
Created Date: 2012-12-3 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8709376 Medline TA: AIDS Res Hum Retroviruses Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Hvidovre University Hospital, Endocrinology, Hvidovre, Denmark; ulrichbangbang@gmail.com. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Dual targeting of hypoxic and acidic tumour environments with a cobalt(III) chaperone complex.
Next Document: Tissue Doppler imaging for diagnosis of coronary artery disease: a systematic review and meta-analys...