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The effect of cholecalciferol and calcitriol on biochemical bone markers in HIV-1 infected males: results of a clinical trial.
MedLine Citation:
PMID:  23199009     Owner:  NLM     Status:  Publisher    
Introduction: HIV-1 infected patients have an increased risk of osteoporosis and fractures. The main objective of this study was to evaluate the bone metabolism in HIV-1 infected patients exposed to calcitriol and cholecalciferol. We also investigated the relationship between T cells and bone markers. Methods: We conducted a placebo controlled randomized study running for 16 weeks including 61 HIV-1 infected males, of whom 51 completed the protocol. Nine-teen participants were randomized to daily treatment with A) 0.5-1.0 μg calcitriol and 1200 IU (30 μg) cholecalciferol, 17 participants to B) 1200 IU cholecalciferol, and 15 participants to C) placebo. At baseline and after 16 weeks, we determined collagen type 1 trimeric cross-linked peptide (CTx), procollagen type 1 N-terminal peptide (P1NP), parathyroid hormone (PTH), ionized calcium, 25-hydroxy vitamin D (25OHD), and 1,25-dihydroxy vitamin D (1,25(OH)2D). We determined naïve CD4+ and CD8+, activated CD4+ and CD8+, and regulatory CD4+CD25+CD127(low) T lymphocytes. Results: Baseline levels of P1NP and CTx correlated (coefficient 0.5, p<0.001) with each other but not with PTH, 25OHD, nor 1,25(OH)2D. In patients receiving calcitriol and cholecalciferol, mean levels of P1NP (p<0.001) and CTx (p=0.002) declined significantly compared to our placebo group. Based on changes in P1NP and CTx, we estimated that net bone formation occurred more frequently in group A compared to group B and C. PTH correlated inversely with naïve CD4+ and CD8+ cells. Otherwise, no relationships between bone markers and T lymphocytes were demonstrated. Conclusion: Supplementation with calcitriol and cholecalciferol induced biochemical indications of bone formation in HIV-1 patients.
Ulrich Christian Bang; Lilian Kolte; Mette Hitz; Louise Lind Schierbeck; Susanne Dam Nielsen; Thomas Benfield; Jens-Erik Beck Jensen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-2
Journal Detail:
Title:  AIDS research and human retroviruses     Volume:  -     ISSN:  1931-8405     ISO Abbreviation:  AIDS Res. Hum. Retroviruses     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8709376     Medline TA:  AIDS Res Hum Retroviruses     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Hvidovre University Hospital, Endocrinology, Hvidovre, Denmark;
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